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논문 기본 정보

자료유형
학술저널
저자정보
Eunju Jeong (Department of Gastroenterology CHA Bundang Medical Center CHA University College of Medicine Seongn) In Kyung Yoo (Department of Gastroenterology CHA Bundang Medical Center CHA University College of Medicine Seongn) Abdullah Ozgur Yeniova (Division of Gastroenterology Department of Internal Medicine Tokat Gaziosmanpa?a University Faculty) Dong Keon Yon (Department of Pediatrics CHA Bundang Medical Center CHA University College of Medicine Seongnam Kor) Joo Young Cho (Department of Gastroenterology CHA Bundang Medical Center CHA University College of Medicine Seongn)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제1호
발행연도
2021.1
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55 - 63 (9page)

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Background/Aims: To date, there is no standard tool to diagnose gastroesophageal reflux disease (GERD). Typically, GERD is anon-erosive reflux disease (NERD) that does not present endoscopic abnormalities. Confocal laser endomicroscopy (CLE) has beenshown to be an effective tool to identify and diagnose GERD. We aimed to investigate the cellular and vascular changes in vivo andex vivo through CLE in patients with GERD. Methods: Patients with refractory GERD who underwent mucosectomy were recruited. The distal esophagus was observed invivo using CLE. Mucosectomy tissue was stained with acriflavine and CLE image was obtained ex vivo. We compared cellular andvascular changes in CLE between erosive reflux disease (ERD), NERD, and a control group. Results: Eleven patients who underwent anti-reflux mucosectomy and five control patients were enrolled in the study. Patientswith ERD and NERD presented greater dilated intercellular space than patients in the control group on CLE image. The diameter,number, and cross-sectional area of the intra-papillary capillary loops (IPCLs) were significantly larger in the ERD group than in theNERD group. The irregular shape of the IPCLs were observed in both patients with ERD and NERD. Conclusions: The irregular shape of the IPCLs were significantly correlated with a positive diagnosis of GERD. CLE may diagnoseNERD with high sensitivity and accuracy.

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