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논문 기본 정보

자료유형
학술저널
저자정보
Ying Huang (Medical School of Nanjing University) Chenjie Xu (Nanjing Medical University) Tao Zeng (Kunshan Hospital of Integrated Traditional Chinese and Western Medicine) Zhongming Li (Affiliated Hospital of Nantong University) Yanzhi Xia (Fudan University) Gaojian Tao (Medical School of Nanjing University) Tong Zhu (Medical School of Nanjing University) Lijuan Lu (Medical School of Nanjing University) Jing Li (Medical School of Nanjing University) Taiyuan Huang (Medical School of Nanjing University) Hongbo Huai (Medical School of Nanjing University) Benxiang Ning (Medical School of Nanjing University) Chao Ma (Medical School of Nanjing University) Xinxing Wang (China-Japan Friendship Hospital) Yuhua Chang (Bayingolin Mongolian Autonomous Prefecture People’s Hospital) Peng Mao (China-Japan Friendship Hospital) Jian Lin (Medical School of Nanjing University)
저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제34권 제2호
발행연도
2021.1
수록면
210 - 216 (7page)

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Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.
#Analgesia #Patient-Controlled #Analgesics #Opioid #Anticonvulsants #Hydromorphone #Neuralgia #Postherpetic #Opiate Alkaloids #Pain #Intractable #Pain Management #Pregabalin.

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참고문헌 (16)

참고문헌 신청
Tsai CC / 2014 / Effect of the herbal drug guilu erxian jiao on muscle strength, articular pain, and disability in elderly men with knee osteoarthritis / Evid Based Complement Alternat Med 2014:297458 google schola Watson CP / 2000 / A new treatment for postherpetic neuralgia / N Engl J Med 343:1563~1565 google schola Schmader KE / 2002 / Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy / Clin J Pain 18:350~354 google schola Johnson RW / 2003 / Treatment of herpes zoster and postherpetic neuralgia / BMJ 326:748~750 google schola Johnson RW / 2010 / The impact of herpes zoster and postherpetic neuralgia on quality-of-life / BMC Med 8:37 google schola

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