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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제6호
- 발행연도
- 2018.11
- 수록면
- 617 - 626 (10page)
- DOI
- 10.1007/s40005-018-0391-7
이용수
초록· 키워드
오류제보하기
During the last 5 years, there has been a marked rise in publications regarding exosomes. Exosomes find potential applications as diagnostic biomarkers, therapeutics, drug delivery vehicles, and functional cosmetics and several exosome-based therapies are under clinical trials. Exosomes are nanosized vesicles that contain cell-derived lipid membranes, nucleic acids, and proteins, and are released from the cells of origin, circulate in eukaryotic fluids, and are taken up by recipient cells. The originating cell can be engineered to express specific genes, which enhance immunity, cross-presentation of antigens, or cell targeting by exosomes. Various methods using centrifugation, size-exclusion chromatography, filtration, precipitation, affinity, and microfluidics have been assessed for the isolation and purification of exosomes from biological samples. In addition, exosomes have advantages as drug delivery systems, with biocompatibility, preservation of cargo drugs during circulation in physiological fluids, uptake into the target cells, and drug release after endosomal escape. In this review, we discuss the various aspects of pharmaceutical investigation into exosomes with special focus on engineering, production, characterization, biological activities, applications of exosomes as drug delivery systems, and regulations for evaluation of exosome products.
목차
등록된 정보가 없습니다.
참고문헌 (100)
참고문헌 신청
Alvarez ML / 2012 / Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers / Kidney Int 82:1024~1032
Baranyai T / 2015 / Isolation of exosomes from blood plasma: qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods / PLoS One 10:e0145686
Boing AN / 2014 / Single-step isolation of extracellular vesicles by size-exclusion chromatography / J Extracell Vesicles 3
Booth AM / 2006 / Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane / J Cell Biol 172:923~935
Bosch S / 2016 / Trehalose prevents aggregation of exosomes and cryodamage / Sci Rep Uk 6:36162
Baranyai T / 2015 / Isolation of exosomes from blood plasma: qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods / PLoS One 10:e0145686
Boing AN / 2014 / Single-step isolation of extracellular vesicles by size-exclusion chromatography / J Extracell Vesicles 3
Booth AM / 2006 / Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane / J Cell Biol 172:923~935
Bosch S / 2016 / Trehalose prevents aggregation of exosomes and cryodamage / Sci Rep Uk 6:36162
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