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Erythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.
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참고문헌 (26)
참고문헌 신청
H. Aebi / 1984 / Catalase in vitro / Methods Enzymol 105:121~126
배춘식 / 2019 / Extracts from Erythronium japonicum and Corylopsis coreana Uyeki reduce 1,3-dichloro-2-propanol-mediated oxidative stress in human hepatic cells / Food Science and Biotechnology 28(1):175~180
C. Beauchamp / 1971 / Superoxide dismutase : Improved assays and an assay applicable to acrylamide gels / Anal. Biochem 44:276~287
부희옥 / 2013 / Carbohydrate, Lipid Inhibitory Activity and Antioxidant Activity of Extracts from Several Economic Resource Plants in Vitro / 한국자원식물학회지 26(3):374~382
K. Choi / 2009 / Oxidative stress-induced necrotic cell death via mitochondria-dependent burst of reactive oxygen species / Curr. Neurovasc. Res 6:213~222
배춘식 / 2019 / Extracts from Erythronium japonicum and Corylopsis coreana Uyeki reduce 1,3-dichloro-2-propanol-mediated oxidative stress in human hepatic cells / Food Science and Biotechnology 28(1):175~180
C. Beauchamp / 1971 / Superoxide dismutase : Improved assays and an assay applicable to acrylamide gels / Anal. Biochem 44:276~287
부희옥 / 2013 / Carbohydrate, Lipid Inhibitory Activity and Antioxidant Activity of Extracts from Several Economic Resource Plants in Vitro / 한국자원식물학회지 26(3):374~382
K. Choi / 2009 / Oxidative stress-induced necrotic cell death via mitochondria-dependent burst of reactive oxygen species / Curr. Neurovasc. Res 6:213~222
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