Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

Na Young Lee; Min Jea Shin; Gi Soo Youn; Sang Jun Yoon; Ye Rin Choi; Hyeong Seop Kim; Haripriya Gupta; Sang Hak Han; Byoung Kook Kim; Do Yup Lee; Tae Sik Park; Hotaik Sung; Byung Yong Kim; Ki Tae Suk

추천

검색

자료유형: 학술저널

저자정보: Na Young Lee (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Min Jea Shin (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Gi Soo Youn (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Sang Jun Yoon (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Ye Rin Choi (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Hyeong Seop Kim (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Haripriya Gupta (Institue for Liver and Digestive Diseases Hallym University College of Medicine) Sang Hak Han (Department of Pathology Hallym University College of Medicine) Byoung Kook Kim (Chong Kun Dang Bio Research Institute) Do Yup Lee (Department of Agricultural Biotechnology Seoul National University) Tae Sik Park (Department of Life Science Gachon University) Hotaik Sung (Department of Medicine College of Medicine Kyungpook National University) Byung Yong Kim (Department of Microbiome ChunLab Inc.) Ki Tae Suk (Institute for Liver and Digestive Diseases Department of Internal Medicine Hallym University Colleg)

저널정보: 대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제1호

발행연도: 2021.1

수록면: 110 - 124 (15page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There is a paucity of research on which strains of gut microbiota affect the progression of NAFLD. This study explored the NAFLD-associated microbiome in humans and the role of Lactobacillus in the progression of NAFLD in mice. Methods: The gut microbiome was analyzed via next-generation sequencing in healthy people (n=37) and NAFLD patients with elevated liver enzymes (n=57). Six-week-old male C57BL/6J mice were separated into six groups (n=10 per group; normal, Western, and four Western diet + strains [109 colony-forming units/g for 8 weeks; L. acidophilus, L. fermentum, L. paracasei, and L. plantarum]). Liver/body weight ratio, liver pathology, serum analysis, and metagenomics in the mice were examined. Results: Compared to healthy subjects (1.6±4.3), NAFLD patients showed an elevated Firmicutes/Bacteroidetes ratio (25.0±29.0) and a reduced composition of Akkermansia and L. murinus (P<0.05). In the animal experiment, L. acidophilus group was associated with a significant reduction in liver/body weight ratio (5.5±0.4) compared to the Western group (6.2±0.6) (P<0.05). L. acidophilus (41.0±8.6), L. fermentum (44.3±12.6), and L. plantarum (39.0±7.6) groups showed decreased cholesterol levels compared to the Western group (85.7±8.6) (P<0.05). In comparison of steatosis, L. acidophilus (1.9±0.6), L. plantarum (2.4±0.7), and L. paracasei (2.0±0.9) groups showed significant improvement of steatosis compared to the Western group (2.6±0.5) (P<0.05). Conclusions: Ingestion of Lactobacillus, such as L. acidophilus, L. fermentum, and L. plantarum, ameliorates the progression of nonalcoholic steatosis by lowering cholesterol. The use of Lactobacillus can be considered as a useful strategy for the treatment of NAFLD.

#Nonalcoholic fatty liver disease #Lactobacillus #Probiotics #Gut microbiome #Cholesterol

참고문헌 (50)

참고문헌 신청

Ascha MS / 2010 / The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis / Hepatology 51:1972~1978

Qin J / 2010 / A human gut microbial gene catalogue established by metagenomic sequencing / Nature 464:59~65

Joseph F. Cavallari / 2017 / Intestinal Microbiota Contributes to Energy Balance, Metabolic Inflammation, and Insulin Resistance in Obesity / Journal of Obesity & Metabolic Syndrome 26(3):161~171

Aragonès G / 2019 / Gut microbiota-derived mediators as potential markers in nonalcoholic fatty liver disease / Biomed Res Int 2019:8507583

Takiishi T / 2017 / Intestinal barrier and gut microbiota: shaping our immune responses throughout life / Tissue Barriers 5:e1373208

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!