지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 741 - 749 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Non-vitamin K antagonist oral anticoagulants (NOACs) are widely used in patients with atrial fibrillation (AF) becauseof their effectiveness in preventing stroke and their better safety, compared with warfarin. However, there are concerns for an increasedrisk of bleeding associated with concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) or selective serotoninreuptake inhibitors (SSRIs) with NOACs. In this study, we aimed to evaluate the risk of bleeding events in individuals takingconcomitant NSAIDs or SSRIs with NOACs after being diagnosed with AF. Materials and Methods: A nested case-control analysis to assess the safety of NSAIDs and SSRIs among NOAC users with AF wasperformed using data from Korean National Health Insurance Service from January 2012 to December 2017. Among patients whowere newly prescribed NOACs, 1233 cases hospitalized for bleeding events were selected, and 24660 controls were determined. Results: The risk of bleeding events was higher in patients receiving concomitant NSAIDs [adjusted odds ratio (aOR) 1.41; 95%confidence interval (CI) 1.24?1.61] or SSRIs (aOR 1.92; 95% CI 1.52?2.42) with NOACs, compared to no use of either drug, respectively. The risk of upper gastrointestinal bleeding was higher in patients receiving concomitant NSAIDs or SSRIs without protonpump inhibitors (PPIs) (NSAIDs: aOR 2.47; 95% CI 1.26?4.83, SSRI: aOR 10.8; 95% CI 2.41?2.48) compared to no use. Conclusion: When NSAIDs or SSRIs are required for NOAC users with AF, physicians need to monitor bleeding events and considerthe use of PPIs, especially for combined use of both drugs or when initiating NOACs treatment.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Lee SR / 2017 / Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population / Int J Cardiol 236:226~231
Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation / 1994 / Analysis of pooled data from five randomized controlled trials / Arch Intern Med 154:1449~1457
Bungard TJ / 2000 / Why do patients with atrial fibrillation not receive warfarin / Arch Intern Med 160:41~46
Chang SH / 2017 / Association between use of non-vitamin K oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation / JAMA 318:1250~1259
Zhang Y / 2020 / Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs : a population-based nested case-control study / Br J Clin Pharmacol 86:1150~1164
Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation / 1994 / Analysis of pooled data from five randomized controlled trials / Arch Intern Med 154:1449~1457
Bungard TJ / 2000 / Why do patients with atrial fibrillation not receive warfarin / Arch Intern Med 160:41~46
Chang SH / 2017 / Association between use of non-vitamin K oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation / JAMA 318:1250~1259
Zhang Y / 2020 / Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs : a population-based nested case-control study / Br J Clin Pharmacol 86:1150~1164
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