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자료유형
학술저널
저자정보
오탁규 (서울대학교) 송인애 (서울대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제12호
발행연도
2020.1
수록면
997 - 1,003 (7page)

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Purpose: We investigated whether long-term aspirin use is associated with 5-year all-cause mortality. Materials and Methods: Participants were individuals aged ≥40 years who were registered in the 2010 sample cohort database ofthe National Health Insurance Service in South Korea. Aspirin users were divided into three groups: continuous users (2006?2010), previous users (2006?2009), and new users (2010). Individuals with a history of coronary artery disease and cerebrovasculardisease were excluded. Five-year all-cause mortality was defined as mortality due to any cause from January 1, 2011 to December31, 2015. Data were analyzed by multivariable Cox regression. Results: In total, 424444 individuals were included. Five-year all-cause mortality was 9% lower in continuous aspirin users thanin unexposed individuals [hazard ratio (HR): 0.91, 95% confidence interval (CI): 0.86?0.97; p=0.003]. Five-year all-cause mortalityrates in the new aspirin users (HR: 1.00, 95% CI: 0.90?1.11; p=0.995) and previous aspirin users (HR: 1.01, 95% CI: 0.94?1.09;p=0.776) were not significantly different from that in unexposed individuals. In the 40?60-year age group, 5-year all-cause mortalityin the continuous aspirin users was 24% lower (HR: 0.76, 95% CI: 0.64?0.90; p=0.002) than that in unexposed individuals. However,in the >60-year age group, there was no significant association between aspirin use and 5-year all-cause mortality (HR: 0.96,95% CI: 0.90?1.02; p=0.199). Conclusion: Long-term aspirin use is associated with reduced 5-year all-cause mortality in healthy adults, especially those aged<60 years.

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