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논문 기본 정보

자료유형
학술저널
저자정보
Jae-Won Hyun (Department of Neurology Division of Clinical Research National Cancer Center Goyang Korea) Yeseul Kim (Research Institute and Hospital of National Cancer Center Goyang Korea) 김호진 (Department of Neurology Division of Clinical Research National Cancer Center Goyang Korea)
저널정보
대한임상신경생리학회 Annals of Clinical Neurophysiology Annals of Clinical Neurophysiology 제23권 제1호
발행연도
2021.1
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46 - 52 (7page)

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Background: We aimed to investigate candidates for serological biomarkers of neuropathic pain in individuals with neuromyelitis optica spectrum disorder (NMOSD). Methods: We analyzed 38 sera samples from 38 participants with NMOSD in National Cancer Center. Neuropathic pain was evaluated using the painDETECT questionnaire. Pain with neuropathic components (painDETECT score ≥ 13) was observed in 22 participants, among whom 17 had definite neuropathic pain (painDETECT score ≥ 19). The remaining 16 participants had non-neuropathic pain (painDETECT score < 13). Serum glial fibrillary acidic protein (GFAP) levels were assessed using a single-molecule array assay. Several cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-10, and IL-17A, were measured by a multiplex bead-based immunoassay. Results: In comparison of NMOSD participants with neuropathic pain components (or definite neuropathic pain) and those with non-neuropathic pain, the absolute values of serum GFAP, TNF-α, IL-6, and IL-10 levels were higher in participants with neuropathic pain components (or definite neuropathic pain), but these findings did not reach statistical significance. Conclusions: Further larger-scale investigations to find reliable serological biomarkers for neuropathic pain in NMOSD are warranted.

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