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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 8 - 23 (16page)
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This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory adipokines and fatty acids (FAs). This condition, in turn, causes systemic inflammation and elevated FA concentrations in the circulation, which links obesity to several pathologies, including impaired insulin signaling in cardiac muscle and a subsequent shift in myocardial substrate oxidation in favor of FAs and reduced cardiac efficiency. This review also argues that efforts to prevent obesity-related cardiometabolic disease should focus on anti-obesogenic strategies to restore normal adipose tissue metabolism.
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참고문헌 (111)
참고문헌 신청
Finucane MM / 2011 / National, regional, and global trends in body-mass index since 1980 : systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants / Lancet 377:557~567
World Health Organization / 2016 / World health statistics 2016 : monitoring health for the SDGs / World Health Organization
Zhang X / 2020 / Geographic variation in prevalence of adult obesity in China : results from the 2013–2014 national chronic disease and risk factor surveillance / Ann Intern Med 172:291~293
Gregor MF / 2011 / Inflammatory mechanisms in obesity / Annu Rev Immunol 29:415~445
Larsen TS / 1985 / Seasonal changes in lipogenesis and lipolysis in isolated adipocytes from Svalbard and Norwegian reindeer / Acta Physiol Scand 123:97~104
World Health Organization / 2016 / World health statistics 2016 : monitoring health for the SDGs / World Health Organization
Zhang X / 2020 / Geographic variation in prevalence of adult obesity in China : results from the 2013–2014 national chronic disease and risk factor surveillance / Ann Intern Med 172:291~293
Gregor MF / 2011 / Inflammatory mechanisms in obesity / Annu Rev Immunol 29:415~445
Larsen TS / 1985 / Seasonal changes in lipogenesis and lipolysis in isolated adipocytes from Svalbard and Norwegian reindeer / Acta Physiol Scand 123:97~104
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