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논문 기본 정보

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학술저널
저자정보
Song Jeong Eun (Department of Internal Medicine Daegu Catholic University School of Medicine Daegu Korea.) Kang Min Kyu (Department of Internal Medicine Yeungnam University College of Medicine Daegu Korea) Lee Yu Rim (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea) Lee Chang Hyeong (Department of Internal Medicine Daegu Catholic University School of Medicine Daegu Korea) Park Jung Gil (Department of Internal Medicine Yeungnam University College of Medicine Daegu Korea) Kweon Young Oh (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea.) Tak Won Young (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea.) Park Soo Young (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea.) Jang Se Young (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea) Hwang Jae Seok (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea.) Jang Byoung Kuk (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea.) Jang Won Young (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea.) Suh Jeong Ill (Department of Internal Medicine Dongguk University College of Medicine Gyeongju Korea.) Chung Woo Jin (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea) Kim Byung Seok (Department of Internal Medicine Daegu Catholic University School of Medicine Daegu Korea.)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
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606 - 615 (10page)

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Background/Aims: Recent data indicate the presence of liver enzyme abnormalities in patients with coronavirus disease 2019 (COVID-19). We aimed to evaluate the clinical features and treatment outcomes of COVID-19 patients with abnormal liver enzymes. Methods: We performed a retrospective, multicenter study of 874 COVID-19 patients admitted to five tertiary hospitals from February 20 to April 14, 2020. Data on clinical features, laboratory parameters, medications, and treatment outcomes were collected until April 30, 2020, and compared between patients with normal and abnormal aminotransferases. Results: Abnormal aminotransferase levels were observed in 362 patients (41.1%), of which 94 out of 130 (72.3%) and 268 out of 744 (36.0%) belonged to the severe and non-severe COVID- 19 categories, respectively. The odds ratios (95% confidence interval) for male patients, patients with a higher body mass index, patients with severe COVID-19 status, and patients with lower platelet counts were 1.500 (1.029 to 2.184, p=0.035), 1.097 (1.012 to 1.189, p=0.024), 2.377 (1.458 to 3.875, p=0.001), and 0.995 (0.993 to 0.998, p>0.001), respectively, indicating an independent association of these variables with elevated aminotransferase levels. Lopinavir/ ritonavir and antibiotic use increased the odds ratio of abnormal aminotransferase levels after admission (1.832 and 2.646, respectively, both p<0.05). The median time to release from quarantine was longer (22 days vs 26 days, p=0.001) and the mortality rate was higher (13.0% vs 2.9%, p<0.001) in patients with abnormal aminotransferase levels. Conclusions: Abnormal aminotransferase levels are common in COVID-19 patients and are associated with poor clinical outcomes. Multivariate analysis of patients with normal aminotransferase levels on admission showed that the use of lopinavir/ritonavir and antibiotics was associated with abnormal aminotransferase levels; thus, careful monitoring is needed.
#SARS-CoV-2 #COVID-19 #Aminotransferase #Prognosis #Lopinavir-ritonavir

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참고문헌 (36)

참고문헌 신청
Jang Jong Geol / 2020 / Prognostic Accuracy of the SIRS, qSOFA, and NEWS for Early Detection of Clinical Deterioration in SARS-CoV-2 Infected Patients / Journal of Korean Medical Science 35(25):1~10 dbpia Tian S / 2020 / Characteristics of COVID-19 infection in Beijing / J Infect 80:401~406 google schola Huang C / 2020 / Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / Lancet 395:497~506 google schola Wang D / 2020 / Clinical characteristics of 138hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China / JAMA 323:1061~1069 google schola Chen N / 2020 / Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China : a descriptive study / Lancet 395:507~513 google schola

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