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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Cardiovascular disease (CVD) is the leading cause of death globally and its major risk factor is cholesterol. Even though statins are often prescribed to lower blood levels of low-density lipoprotein cholesterol (LDL-C), not all the high-risk patients were able to achieve a targeted level of LDL-C. PCSK9 protein plays a major role in LDL receptor degradation and is a prominent modulator in LDL-C metabolism. Two monoclonal antibodies inhibiting PCSK9, evolocumab and alirocumab, are approved by the US FDA in 2015. Anti-PCSK9 antibody drugs could lead to a substantial decrement in LDL-C plasma level, either as a monotherapy or combination with statins. Moreover, PCSK9 inhibitors do not appear to increase the risk of hepatic and muscle-related side effects. Here, the Fab fragment of evolocumab was overexpressed, purified, and crystallized. The crystal diffracted to 2.00 A resolution and belonged to the space group R32, with unit cell parameters a = b = 107.09, and c = 182.39 A. An asymmetric unit of the crystal contains one Fab molecule of evolocumab with a VM of 2.32 A3 Da-1 and a solvent content of 47.00%.
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참고문헌 (16)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Alali, R. A. / 2019 / A short review of proprotein convertase subtilisin/kexin type 9 inhibitors / Rev Cardiovasc Med 20:1~8
Androulakis, E. / 2017 / High-density lipoprotein and low-density lipoprotein therapeutic approaches in acute coronary syndromes / Curr Cardiol Rev 13:168~182
Bentzon, J. F. / 2014 / Mechanisms of plaque formation and rupture / Circ Res 114:1852~1866
Blanchard, V. / 2019 / PCSK9 : from biology to clinical applications / Pathology 51:177~183
Alali, R. A. / 2019 / A short review of proprotein convertase subtilisin/kexin type 9 inhibitors / Rev Cardiovasc Med 20:1~8
Androulakis, E. / 2017 / High-density lipoprotein and low-density lipoprotein therapeutic approaches in acute coronary syndromes / Curr Cardiol Rev 13:168~182
Bentzon, J. F. / 2014 / Mechanisms of plaque formation and rupture / Circ Res 114:1852~1866
Blanchard, V. / 2019 / PCSK9 : from biology to clinical applications / Pathology 51:177~183
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