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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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CD38 is a type II transmembrane glycoprotein highly expressed in diverse hematologic malignancies including B-cell non- Hodgkin lymphoma and multiple myeloma cells. CD38 overexpressed on the surface of multiple myeloma cells has been highlighted as a good target for therapeutic agents. In 2020, the US FDA approved isatuximab, an anti-CD38 monoclonal antibody, for the treatment of multiple myeloma. Here, the recombinant proteins of the ectodomain of CD38 and the Fab fragment of isatuximab were expressed, and their binding complex was purified and crystallized. The crystal diffracted to 1.90 A resolution and belonged to the space group C2, with unit cell parameters a = 217.75, b = 43.17, c = 81.73 A, and β = 103.75°. An asymmetric unit of the crystal contains one molecule of the complex with a VM of 2.33 A3 Da?1 and a solvent content of 47.31%.
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참고문헌 (14)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Bonello, F. / 2018 / CD38 as an immunotherapeutic target in multiple myeloma / Expert Opin Biol Ther 18:1209~1221
Deckert, J. / 2014 / SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+hematologic malignancies / Clin Cancer Res 20:4574~4583
de Weers, M. / 2011 / Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors / J Immunol 186:1840~1848
Dhillon, S. / 2020 / Isatuximab : first approval / Drugs 80:905~912
Bonello, F. / 2018 / CD38 as an immunotherapeutic target in multiple myeloma / Expert Opin Biol Ther 18:1209~1221
Deckert, J. / 2014 / SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+hematologic malignancies / Clin Cancer Res 20:4574~4583
de Weers, M. / 2011 / Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors / J Immunol 186:1840~1848
Dhillon, S. / 2020 / Isatuximab : first approval / Drugs 80:905~912
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