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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 613 - 613 (1page)
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Specific delivery of anti-tumor drugs (chemical drugs, genetic materials, and proteins) to tumor tissues or cells is very important to reduce cytotoxicity and dosage. To find specific tumor-targeting molecules, it will be a very important key point in the development of next-generation anticancer drugs. Therefore, we investigated the potential of curcumin and its derivatives as a novel cancer-targeting ligand and suitable structure among phenylalanine (Ph), cinnamic acid (Ci), coumaric acid (Co), ferulic acid (Fe), and curcumin (Cu) which are produced in biosynthesis pathway of curcumin. Dextran grafted with branched polyethylenimine (bPEI) (DP) and lysine dendrimer peptide conjugated without (dK) or with PEGylated targeting ligands (dKPh, dKCi, dKCo, dKFe, and dKCu) were successfully synthesized and their mixtures formulated in 9.5:0.5, 9:1, and 8:2 w/w ratios were used as a targeted gene carrier (DPK, DPKPh, DPKCi, DPKCo, DPKFe, and DPKCu). All tested gene carriers showed an excellent DNA-binding capability, DNA protection ability from a nuclease, and exhibited condensation ability to ... 전체 초록 보기
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