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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 616 - 616 (1page)
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In vitro transcribed (IVT) mRNA is considered as a new gene regulation tool for therapeutic application with its rapid expression and low immunogenicity. Natural killer (NK) cells have attracted attention due to proinflammatory and cytotoxic function toward solid tumors. Genetically-modified NK cells show high viability and tumor targeting ability but there are few reports on optimal IVT mRNA transfection conditions for NK cells. We formulated polymeric nanoparticles between cationic polymer, PAsp(DET/CHE) and firefly-luciferase (F-Luc) mRNA. The polymer contains two moieties; DET triggers en ... 전체 초록 보기
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