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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 122 - 127 (6page)
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초록· 키워드
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Objectives: Increasing bone mineral density (BMD) to reduce fracture risk is a primary goal of osteoporosis treatment. This prospective, observational study evaluates the effects of monthly minodronate (MIN; 50 mg) with or without eldecalcitol (ELD) addition in osteoporosis patients with rheumatoid arthritis (RA) during 18 months. Methods: The cohort was prospectively and randomly split into the MIN monotherapy group (14 cases) and MIN plus ELD group (combination group; 14 cases) due to no reports on the effectiveness and safety of MIN therapy in relation to ELD addition for comparisons of serum tartrate-resistant acid phosphatase (TRACP)-5b, bone alkaline phosphatase (BAP), and BMD of the lumbar 1e4 vertebrae (L-BMD), bilateral total hips (H-BMD; the mean value of the right and left hips), and bilateral femoral necks (FN-BMD) at baseline and at 6, 12, and 18 months of treatment. Results: Baseline values were comparable between the groups apart from a tendency for higher TRACP- 5b in the combination group. Seven of 14 patients in the combination group had received previous bisphosphonate treatment. BAP was significantly more reduced in the monotherapy group at 6 months, with no other remarkable differences for TRACP5b, L-BMD, H-BMD, or FN-BMD during the observation period. Conclusions: The above findings suggest that regardless of ELD addition, MIN potentially improves BMD during 18 months in osteoporosis patients with RA.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Cosman F / 2014 / Clinician’s guide to prevention and treatment of osteoporosis / Osteoporos Int 25:2359~2381
Matsumoto T / 2009 / Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis : a randomized placebocontrolled double-blind study / Osteoporos Int 20:1429~1437
Hagino H / 2012 / Three years of treatment with minodronate in patients with postmenopausal osteoporosis / J Bone Miner Metab 30:439~446
Hasegawa E / 2018 / The efficacy of minodronate in the treatment of glucocorticoid-induced osteoporosis / Intern Med 57:2169~2178
Nakamura Y / 2017 / Alfacalcidol increases the therapeutic efficacy of ibandronate on bone mineral density in Japanese women with primary osteoporosis / Tohoku J Exp Med 241:319~326
Matsumoto T / 2009 / Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis : a randomized placebocontrolled double-blind study / Osteoporos Int 20:1429~1437
Hagino H / 2012 / Three years of treatment with minodronate in patients with postmenopausal osteoporosis / J Bone Miner Metab 30:439~446
Hasegawa E / 2018 / The efficacy of minodronate in the treatment of glucocorticoid-induced osteoporosis / Intern Med 57:2169~2178
Nakamura Y / 2017 / Alfacalcidol increases the therapeutic efficacy of ibandronate on bone mineral density in Japanese women with primary osteoporosis / Tohoku J Exp Med 241:319~326
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