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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 77 - 85 (9page)
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Purpose: We investigated the prognostic significance of CD9 expression in tumor cells of patients with invasive lobular carcinoma (ILC). Methods: CD9 expression was evaluated by immunohistochemistry in 113 ILC tissue samples. Correlation of CD9 expression with the patients' clinicopathological parameters and overall survival was assessed. Results: CD9 expression was detected in 48 (42.5%) ILC patients. However, no significant relation could be determined between CD9 expression and the clinicopathological parameters of the patient including tumor size, lymph node metastasis, lymphovascular invasion, histologic grade, expression of hormone receptors, human epidermal growth factor receptor 2 status, and Ki-67 labeling index. Patients with CD9 expression had worse overall survival (p = 0.051) and disease-free survival (DFS, p = 0.014) compared to patients without CD9 expression. Multivariate analysis revealed that CD9 expression was an independent prognostic factor for DFS (p = 0.049). Conclusion: CD9 expression in tumor cells could be a significant prognostic marker in patients with ILC.
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참고문헌 (24)
참고문헌 신청
Lazo PA / 2007 / Functional implications of tetraspanin proteins in cancer biology / Cancer Sci 98:1666~1677
Stipp CS / 2003 / Functional domains in tetraspanin proteins / Trends Biochem Sci 28:106~112
Huang C / 1997 / MRP-1/CD9 and KAI1/CD82 expression in normal and various cancer tissues / Int J Oncol 11:1045~1051
Miyake M / 1996 / Motility-related protein-1(MRP-1/CD9)reduction as a factor of poor prognosis in breast cancer / Cancer Res 56:1244~1249
Huang CI / 1998 / Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients / Am J Pathol 153:973~983
Stipp CS / 2003 / Functional domains in tetraspanin proteins / Trends Biochem Sci 28:106~112
Huang C / 1997 / MRP-1/CD9 and KAI1/CD82 expression in normal and various cancer tissues / Int J Oncol 11:1045~1051
Miyake M / 1996 / Motility-related protein-1(MRP-1/CD9)reduction as a factor of poor prognosis in breast cancer / Cancer Res 56:1244~1249
Huang CI / 1998 / Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients / Am J Pathol 153:973~983
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