Prognostic Role of KRAS mRNA Expression in Breast Cancer

Ki-Tae Hwang; 김병혁; Sohee Oh; So Yeon Park; Jiwoong Jung; 김종진; In Sil Choi; Sook Young Jeon; 김우영

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자료유형: 학술저널

저자정보: Ki-Tae Hwang (Department of Surgery Seoul Metropolitan Government-Seoul National University Boramae Medical Cente) 김병혁 (서울특별시보라매병원) Sohee Oh (Department of Biostatistics Seoul Metropolitan Government Seoul National University Boramae Medical) So Yeon Park (Department of Pathology Seoul National University College of Medicine) Jiwoong Jung (Department of Surgery Seoul Medical Center Seoul Korea) 김종진 (서울특별시보라매병원) In Sil Choi (Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Med) Sook Young Jeon (Department of Surgery Graduate School Kyung Hee University) 김우영 (숙명여자대학교)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.22 No.4

발행연도: 2019.1

수록면: 548 - 561 (14page)

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Purpose: We investigated the prognostic role of KRAS mRNA expression in breast cancer using The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases. Methods: Clinical and biological data of 1,093 breast cancers from TCGA database and 1,904 breast cancers from METABRIC database were analyzed. Overall survival (OS) and breast cancer-specific survival (BCSS) were determined. Results: The group with high KRAS mRNA expression showed worse survival than the group with low KRAS mRNA expression regarding both OS (p = 0.012 in TCGA, p < 0.001 in METABRIC) and BCSS (p = 0.001 in METABRIC). According to multivariate analysis, the level of KRAS mRNA expression was an independent prognostic factor in both TCGA (hazard ratio [HR], 1.570; 95% confidence interval [CI], 1.026–2.403; p = 0.038) and METABRIC (HR, 1.254; 95% CI, 1.087–1.446; p = 0.002) databases. The prognostic impact of mRNA expression was effective only for luminal A subtype (p < 0.001 in METABRIC). Positive correlation was observed between mRNA expression and copy number alteration (CNA) (r = 0.577, p < 0.001 in TCGA; ρ = 0.343, p < 0.001 in METABRIC). Methylation showed negative correlations with both mRNA expression and CNA (r = −0.272, p < 0.001 in TCGA). The expression of mRNA had little association with the mutation status in breast cancers, having a mutation frequency of approximately 0.6%. Conclusion: KRAS mRNA expression was significantly associated with breast cancer prognosis. It was found to be an independent prognostic factor for breast cancer. Prognostic role of KRAS mRNA expression was effective only in luminal A subtype. Further studies are needed to validate the prognostic role of KRAS mRNA expression in breast cancer, thus paving a way for clinical application of KRAS in practice.

#Breast neoplasms #Prognosis #ras Proteins #RNA

참고문헌 (30)

참고문헌 신청

Goitre L / 2014 / Ras Signaling: Methods and Protocols. Methods in Molecular Biology. Vol 1120 / Humana Press :1~18

Biankin AV / 2012 / Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes / Nature 491:399~405

Cancer Genome Atlas Network / 2012 / Comprehensive molecular characterization of human colon and rectal cancer / Nature 487:330~337

Cancer Genome Atlas Research Network / 2014 / Comprehensive molecular profiling of lung adenocarcinoma / Nature 511:543~550

Prior IA / 2012 / A comprehensive survey of Ras mutations in cancer / Cancer Res 72:2457~2467

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