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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 104 - 110 (7page)
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Objective. To examine whether bone mineral density (BMD) is causally associated with osteoarthritis (OA). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighting (IVW), weighted median, and MR-Egger regression methods. We used publicly available summary statistics datasets of a genome-wide association study (GWAS) on femur neck (FN) BMD of individuals of European ancestry as the exposure and a GWAS for non-cancer illness code self-reported: OA from the individuals included in the UK Biobank as the outcome. Results. We selected 21 independent single- nucleotide polymorphisms with genome-wide significance (p＜5.00E-08) from GWAS on FN BMD as the instrumental variables. The IVW method (beta=0.010, standard error [SE]=0.003, p=0.002) and the weighted median approach (beta=0.011, SE=0.004, p=0.006) yielded evidence of a causal association between FN BMD and OA. However, the MR-Egger analysis showed no causal association between FN BMD and OA (beta=0.005, SE=0.017, p=0.753). Since MR-Egger regression suffers from a lack of power and a susceptibility to weak instrument bias, the MR analysis results may support a causal association between FN BMD and OA. Conclusion. The results of MR analysis by IVW and weighted median, but not MR-Egger regression indicate that FN BMD is likely to be causally associated with an increased risk of OA incidence The current findings may provide an opportunity to elucidate the underlying mechanisms of the effects of BMD on the OA incidence.
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참고문헌 (26)
참고문헌 신청
Dieppe PA / 2005 / Pathogenesis and management of pain in osteoarthritis / Lancet 365:965~973
Litwic A / 2013 / Epidemiology and burden of osteoarthritis / Br Med Bull 105:185~199
Silverwood V / 2015 / Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis / Osteoarthritis Cartilage 23:507~515
Eun Hye Park / 2018 / Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes / 대한류마티스학회지 25(3):188~196
Hart DJ / 2002 / The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford study / Arthritis Rheum 46:92~99
Litwic A / 2013 / Epidemiology and burden of osteoarthritis / Br Med Bull 105:185~199
Silverwood V / 2015 / Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis / Osteoarthritis Cartilage 23:507~515
Eun Hye Park / 2018 / Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes / 대한류마티스학회지 25(3):188~196
Hart DJ / 2002 / The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford study / Arthritis Rheum 46:92~99
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