지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Axial spondyloarthritis (axSpA) is a chronic inflammatory joint disease with a predilection for the spine. It affects young adults and has the potential to have a major impact on quality of life, not only because of the chronic pain and fatigue, but also because of the potential for marked disability related to spinal ankylosis. Early detection of axSpA remains a major challenge, for which there is a heightened sense of urgency since it has been shown that earlier intervention with biologics can alter the progression of radiographic change in the spine. Advances in the genetics of axSpA have highlighted a number of candidate genes conferring susceptibility to the disease, but there is evidence of environmental factors playing a role as well. Recently studies in both clinical and experimental axSpA have implicated alterations in the gut microbiome as playing a key role, and the immunology of the gut-joint axis is becoming better understood. The unmet needs which are shaping the research agenda include improvement in early case identification, sensitive and specific biomarkers which could accurately reflect disease activity and severity, improved understanding of the common pathways of inflammation in the skin, eye and gut in axSpA, and novel therapeutic targets which could have curative potential.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Haroon N / 2013 / The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis / Arthritis Rheum 65:2645~2654
Koo BS / 2020 / Tumour necrosis factor inhibitors slow radiographic progression in patients with ankylosing spondylitis : 18-year real-world evidence / Ann Rheum Dis 79:1327~1332
Tsui FW / 2014 / Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis / Ann Rheum Dis 73:1873~1879
Akram A / 2014 / HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent / J Immunol 192:5520~5528
Tavasolian F / 2021 / HLA, immune response, and susceptibility to COVID-19 / Front Immunol 11:601886
Koo BS / 2020 / Tumour necrosis factor inhibitors slow radiographic progression in patients with ankylosing spondylitis : 18-year real-world evidence / Ann Rheum Dis 79:1327~1332
Tsui FW / 2014 / Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis / Ann Rheum Dis 73:1873~1879
Akram A / 2014 / HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent / J Immunol 192:5520~5528
Tavasolian F / 2021 / HLA, immune response, and susceptibility to COVID-19 / Front Immunol 11:601886
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
축형 척추관절염의 새로운 약물 치료
대한내과학회지
2018 .01
-
Assessments of Functioning in Patients With Axial Spondyloarthritis
대한류마티스학회지
2020 .01
-
Association of Uveitis with Radiographic Progression in Patients with Axial Spondyloarthritis: A Propensity Score Matching Analysis
대한류마티스학회지
2019 .01
-
Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort
대한류마티스학회지
2020 .01
-
The effectiveness of tumor necrosis factor-α blocker therapy in patients with axial spondyloarthritis who failed conventional treatment: a comparative study focused on improvement in ASAS Health Index
대한류마티스학회지
2024 .07
-
강직성 척추염의 병태 생리
대한류마티스학회지
2015 .01
-
Are Platelet Indices of Clinical Use to Monitor Disease Activity and Inflammatory Burden in Axial Spondyloarthritis?
대한류마티스학회지
2016 .01
-
The Epidemiology and Treatment of Ankylosing Spondylitis in Korea
대한류마티스학회지
2022 .10
-
Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors
Immune Network
2021 .06
-
Progressive Pulmonary Fibrocystic Changes of Both Upper Lungs in a Patient with Ankylosing Spondylitis
Tuberculosis and Respiratory Diseases
2015 .01
-
Corrigendum: Korean treatment recommendations for patients with axial spondyloarthritis
대한류마티스학회지
2024 .01
-
만성질환을 가진 성인의 미충족 의료 영향요인
지역사회간호학회지
2021 .06
-
Ultrasound-guided epidural block in axial spondyloarthritis patients with limited spine mobility: a randomized controlled trial
The Korean Journal of Pain
2021 .01
-
강직성 척추염 환자에서 발생한 일반 방사선 사진으로 확인되지 않은 흉추의 파열골절 1례
대한응급의학회지
2016 .01
-
Revolutionizing gut health: exploring the role of gut microbiota and the potential of microbiome-based therapies in lower gastrointestinal diseases
고신대학교 의과대학 학술지
2023 .06
-
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Clinical and Molecular Hepatology
2021 .01
-
Comparative analysis of gut microbiome related to weight gain of the same individual before and after gut microbiome replacement
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Piriformis syndrome as an overlooked cause of pain in a patient with axial spondyloarthritis: a case report
대한류마티스학회지
2024 .04
-
Toothache associated with ankylosing spondylitis
Oral Biology Research
2018 .01
-
Ginseng as a therapeutic target to alleviate gut and brain diseases via microbiome regulation
Journal of Ginseng Research
2025 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0