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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 133 - 142 (10page)
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초록· 키워드
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Objective. Systemic lupus erythematosus (SLE) is a common chronic autoimmune inflammatory disease. According to recent studies, signaling through Toll-like receptor (TLR) protein, which promotes the production of inflammatory cytokines, leads to the development of SLE. TLR-inhibitory peptide 1 (TIP1) has been newly identified for the treatment of autoimmune diseases. Methods. The effect of TIP1 was analyzed in an SLE mouse model (MRL/lpr). The mice in the control treatment group (n=5) were administered an intravenous injection of phosphate-buffered saline twice weekly, whereas the mice in the TIP1 treatment group (n=6) were administered an intravenous injection of TIP1 (1 nmol/g) twice weekly. MRL/mpj mice (n=5) were selected as normal controls. The mice were injected for 4 weeks between 14 and 18 weeks of age, followed by assays of their spleen, kidneys, lymph nodes, serum, and urine. Results. The antinuclear antibody and inflammatory cytokine (interferon-α) in the serum as well as levels of albumin in the urine of the mice in the TIP1 treatment group had decreased when compared to those of mice in the control treatment group. Kidney inflammation in mice in the TIP1 treatment group was alleviated. The mRNA expression levels of TLR7- or TLR9-related downstream signaling molecules also decreased in all organs of the mice in the TIP1 treatment group. Conclusion. Intravenous treatment with TIP1 reduces symptoms and markers of inflammation in MRL/lpr mice. Hence, TIP1 is a promising medication for the treatment of SLE.
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참고문헌 (35)
참고문헌 신청
Tsokos GC / 2011 / Systemic lupus erythematosus / N Engl J Med 365:2110~2121
Klippel JH / 1997 / Systemic lupus erythematosus: demographics, prognosis, and outcome / J Rheumatol Suppl 48:67~71
Petri M / 2001 / Long-term outcomes in lupus / Am J Manag Care 7(16 Suppl):S480~S485
Toblli JE / 1983 / Hematologic manifestations in systemic lupus erythematosus. Experience collected from 150 cases / Rev Clin Esp 169:257~261
Kamen DL / 2014 / Environmental influences on systemic lupus erythematosus expression / Rheum Dis Clin North Am 40:401~412
Klippel JH / 1997 / Systemic lupus erythematosus: demographics, prognosis, and outcome / J Rheumatol Suppl 48:67~71
Petri M / 2001 / Long-term outcomes in lupus / Am J Manag Care 7(16 Suppl):S480~S485
Toblli JE / 1983 / Hematologic manifestations in systemic lupus erythematosus. Experience collected from 150 cases / Rev Clin Esp 169:257~261
Kamen DL / 2014 / Environmental influences on systemic lupus erythematosus expression / Rheum Dis Clin North Am 40:401~412
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