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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 204 - 204 (1page)
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Certain cytokines (such as IFN-α) and immune cells play an important role in the pathogenesis of SLE. IFN-α, mainly produced by monocytes is related to causing autoantibodies and glomerulonephritis. Recent studies have identified the relationship between cysteine protease cathepsin S (CTSS) and SLE. In this study, we used CTSS-overexpressing transgenic(TG) mice and induced lupus like symptoms by administrating pristane to examine CTSS functional contribution to lupus pathogenesis. And identify that not only which cell and cytokines are involved pristane induced SLE but also CTSS used as a therapeutic target for SLE and lupus nephritis. Eight months later, the TG mice spontaneously ... 전체 초록 보기
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