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논문 기본 정보

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학술저널
저자정보
Yoon Gwang-Seok (Division of Cardiology Department of Internal Medicine Cardiovascular Center Seoul National Univers) Choi Seong Huan (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Woo Seong-Ill (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Baek Yong-Soo (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Park Sang-Don (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Shin Sung-Hee (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Kim Dae-Hyeok (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Kwan Jun (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha) Lee Man-Jong (Division of Critical Care Medicine Department of Hospital Medicine Inha University Hospital Incheon) Kwon Sung Woo (Division of Cardiology Department of Internal Medicine Inha University College of Medicine and Inha)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.19
발행연도
2021.1
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1 - 9 (9page)

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Background: The neutrophil-to-lymphocyte ratio (NLR) has been proven to be a reliable inflammatory marker. A recent study reported that elevated NLR is associated with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI). We investigated whether NLR at emergency room (ER) is associated with mechanical complications of STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 744 patients with STEMI who underwent successful primary PCI from 2009 to 2018 were enrolled in this study. Total and differential leukocyte counts were measured at ER. The NLR was calculated as the ratio of neutrophil count to lymphocyte count. Patients were divided into tertiles according to NLR. Mechanical complications of STEMI were defined by STEMI combined with sudden cardiac arrest, stent thrombosis, pericardial effusion, post myocardial infarction (MI) pericarditis, and post MI ventricular septal rupture, free-wall rupture, left ventricular thrombus, and acute mitral regurgitation during hospitalization. Results: Patients in the high NLR group (> 4.90) had higher risk of mechanical complications of STEMI (P = 0.001) compared with those in the low and intermediate groups (13% vs. 13% vs. 23%). On multivariable analysis, NLR remained an independent predictor for mechanical complications of STEMI (RR = 1.947, 95% CI = 1.136–3.339, P = 0.015) along with symptom-to balloon time (P = 0.002) and left ventricular dysfunction (P < 0.001). Conclusion: NLR at ER is an independent predictor of mechanical complications of STEMI undergoing primary PCI. STEMI patients with high NLR are at increased risk for complications during hospitalization, therefore, needs more intensive treatment after PCI.
#Neutrophil-to-Lymphocyte Ratio #Mechanical Complications of STEMI #Prognosis

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참고문헌 (22)

참고문헌 신청
Tamhane UU / 2008 / Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome / Am J Cardiol 102(6):653~657 google schola Kurtul A / 2015 / Increased neutrophil-to-lymphocyte ratio predicts persistent coronary no-flow after wire insertion in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention / Clinics(Sao Paulo) 70(1):34~40 google schola Chen Chen / 2018 / Neutrophil to lymphocyte ratio as a predictor of myocardial damage and cardiac dysfunction in acute coronary syndrome patients / Integrative Medicine Research 7(2):192~199 Crossref Temiz A / 2014 / Platelet/lymphocyte ratio and risk of inhospital mortality in patients with ST-elevated myocardial infarction / Med Sci Monit 20:660~665 google schola Arbel Y / 2014 / Higher neutrophil/lymphocyte ratio is related to lower ejection fraction and higher long-term all-cause mortality in STelevation myocardial infarction patients / Can J Cardiol 30(10):1177~1182 google schola

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