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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 855 - 867 (13page)
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초록· 키워드
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Background Cardiovascular diseases contribute to the leading cause of deaths (31%) in the world population. Objective The objective of this study is to compile non-coding RNA-gene interaction into a core regulatory network whose dysregulation might play an important role in disease progression. Method We applied a structured approach to reconstruct the interaction network of lncRNAs, miRNAs and genes involved in cardiovascular diseases. For network construction, we used ‘diseasome to interactome’ and ‘interactome to diseasome’ approaches and developed two regulatory networks in heart disorders. In diseasome to interactome approach, starting from a disease-centric network we, expanded the data into an interaction network. However in interactome to diseasome, we used a set of guide genes, miRNAs and lncRNAs to arrive at the common diseases. The disease-centric network in combination with the interaction network will shed light on the interconnected components in a huge diseasome network implicated in heart disorders and manifested through small sub-networks while progressing. Using the above networks we created a subnetworks consisting only of hub genes, miRNAs and lncRNAs on both approaches. The dysregulation of any one of the hubs can lead to a disease condition. Results The top ranking hubs common in both the sub-networks were found to be VEGFA, MALAT1, HOTAIR, H19 and hsa-miR-15a. Our network based study reveals an entanglement of regulatory sub-network of miRNAs, lncRNAs and genes in multiple conditions. Conclusion The identification of hubs in the core triple node network of elements in disease development and progression demonstrates a promising role for network based approaches in targeting critical molecules for drug development.
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참고문헌 (44)
참고문헌 신청
Abdulle LE / 2019 / MALAT1 as a diagnostic and therapeutic target in diabetes-related complications : a promising long-noncoding RNA / Int J Med Sci 16:548~555
Bai H / 2019 / Comprehensive analysis of lncRNA–miRNA–mRNA during proliferative phase of rat liver regeneration / J Cell Physiol 234:18897~18905
Bunch H / 2018 / Gene regulation of mammalian long non-coding RNA / Mol Genet Genom 293:1~15
Carlsson L / 2018 / Biocompatible, Purified VEGF-A mRNA improves cardiac function after intracardiac injection 1week post-myocardial infarction in swine / Mol Ther Methods Clin Dev 9:330~346
Chen G / 2013 / LncRNADisease : a database for long-non-coding RNA-associated diseases / Nucleic Acids Res 41:D983~D986
Bai H / 2019 / Comprehensive analysis of lncRNA–miRNA–mRNA during proliferative phase of rat liver regeneration / J Cell Physiol 234:18897~18905
Bunch H / 2018 / Gene regulation of mammalian long non-coding RNA / Mol Genet Genom 293:1~15
Carlsson L / 2018 / Biocompatible, Purified VEGF-A mRNA improves cardiac function after intracardiac injection 1week post-myocardial infarction in swine / Mol Ther Methods Clin Dev 9:330~346
Chen G / 2013 / LncRNADisease : a database for long-non-coding RNA-associated diseases / Nucleic Acids Res 41:D983~D986
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