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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 150 - 159 (10page)
- DOI
- 10.14348/molcells.2018.2305
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초록· 키워드
오류제보하기
Animals use their odorant receptors to receive chemical information from the environment. Insect odorant recep-tors differ from the G protein-coupled odorant receptors in vertebrates and nematodes, and very little is known about their protein?protein interactions. Here, we introduce a mass spectrometric platform designed for the large-scale analysis of insect odorant receptor protein?protein interactions. Using this platform, we obtained the first Orco interactome from Drosophila melanogaster. From a total of 1,186 identified proteins, we narrowed the interaction candidates to 226, of which only two-thirds have been named. These candidates include the known olfactory proteins Or92a and Obp51a. Around 90% of the proteins having published names likely function inside the cell, and nearly half of these intracellular proteins are associated with the endomembrane system. In a basic loss-of-function electrophysiological screen, we found that the disruption of eight (i.e., Rab5, CG32795, Mpcp, Tom70, Vir-1, CG30427, Eaat1, and CG2781) of 28 randomly selected candidates affects olfactory responses in vivo. Thus, because this Orco interactome includes physiologically meaningful candidates, we anticipate that our platform will help guide further research on the molecular mechanisms of the insect odorant receptor family.
목차
등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Ai, M. / 2013 / Ionotropic glutamate receptors IR64a and IR8a form a functional odorant receptor complex in vivo in Drosophila / J. Neurosci. 33:10741~10749
Anholt, R.R. / 2010 / The soluble proteome of the Drosophila antenna / Chem. Senses 35:21~30
Bahk, S. / 2016 / Insect odorant receptor trafficking requires calmodulin / BMC Biol 14:83
Bargmann, C.I / 2006 / Comparative chemosensation from receptors to ecology / Nature 444:295~301
Benton, R. / 2015 / Multigene family evolution: perspectives from insect chemoreceptors / Trends Ecol. Evol. 30:590~600
Anholt, R.R. / 2010 / The soluble proteome of the Drosophila antenna / Chem. Senses 35:21~30
Bahk, S. / 2016 / Insect odorant receptor trafficking requires calmodulin / BMC Biol 14:83
Bargmann, C.I / 2006 / Comparative chemosensation from receptors to ecology / Nature 444:295~301
Benton, R. / 2015 / Multigene family evolution: perspectives from insect chemoreceptors / Trends Ecol. Evol. 30:590~600
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