The Tim gene family in efferocytosis

Deokhwan Kim; Sang‑Ah Lee; Hyunji Moon; Kwanhyeong Kim; Daeho Park

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자료유형: 학술저널

저자정보: Deokhwan Kim (Gwangju Institute of Science) Sang‑Ah Lee (Gwangju Institute of Science) Hyunji Moon (Gwangju Institute of Science) Kwanhyeong Kim (Gwangju Institute of Science) Daeho Park (Gwangju Institute of Science)

저널정보: 한국유전학회 Genes & Genomics Genes & Genomics Vol.42 No.9

발행연도: 2020.1

수록면: 979 - 986 (8page)

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One of the key features of the plasma membrane is the asymmetrical distribution of phospholipids across it. Especially, phosphatidylserine (PS) exclusively locates on its inner leafet. Thus, the exposure of PS on the surface of cells could function as a signal initiating various cellular processes such as phagocytosis of apoptotic cells called eferocytosis, blood clotting, muscle formation, and viral entry. Indeed, PS on apoptotic cells stimulates phagocytes to engulf them and functions as an essential ligand for eferocytosis. Due to the importance of PS in eferocytosis, the existence of the PS receptor had been conceived. However, the PS receptor had not been revealed for a long time. Thus, the frst identifcation of the PS receptor was signifcant excitement. Tim-4, a member of the T cell immunoglobulin and mucin domain containing family of genes, was one of PS receptors which frst identifed and received the greatest attention due to its expression in macrophages and relevance to autoimmune and allergic diseases. This review will serve to provide a comprehensive overview of Tim proteins as PS receptors.

#Phosphatidylserine · Phosphatidylserine receptor · Eferocytosis · Timd · Tim-4

참고문헌 (61)

참고문헌 신청

Anderson AC / 2010 / T-bet, a Th1 transcription factor regulates the expression of Tim-3 / Eur J Immunol 40:859~866

Binne LL / 2007 / Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals / J Immunol 178:4342~4350

Brugnera E / 2002 / Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex / Nat Cell Biol 4:574~582

Chen TT / 2005 / TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis / J Exp Med 202:955~965

Curtiss ML / 2011 / Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1(Tim-1) / Mol Immunol 48:1424~1431

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