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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,327 - 1,338 (12page)
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Background Lactobacillus reuteri I5007 possesses many excellent probiotic characteristics in piglets. miRNA plays importantrole in host-microbiota interactions, but the mechanism by which L. reuteri I5007 regulates intestinal function throughits influence on miRNA expression is unknown. Objective This study analyzed the miRNA expression patterns in the ileum mucosa tissue of piglets by L. reuteri I5007treatment, aim to clarify its molecular mechanism for regulating intestinal function through miRNA. Methods Neonatal piglets were orally administered L. reuteri I5007 or a placebo daily starting on day 1, and differentialexpression of ileal miRNAs was analyzed at 10 and 20 days of age by small RNA sequencing. Results 361 known porcine miRNAs were identified, and ten miRNAs were highly expressed in the ileum mucosa in bothtreatments. Nineteen differentially expressed (DE) miRNAs were identified in response to L. reuteri treatment, and four DEmiRNAs (ssc-miR-196a, -196b-5p, -1285 and -10386) were differentially expressed at both time points. The KEGG pathwayanalyses showed the targets of 19 DE miRNAs were involved in 63 significantly enriched pathways, including the PI3KAktand MAPK pathways, which were confirmed to play important roles in probiotic-host communication. L. reuteri I5007exerted anti-inflammatory effects by influencing the levels of inflammatory cytokines. Suppressor of cytokine signalling 4gene was the target gene of ssc-miR-196a/-196b-5p, overexpression of ssc-miR-196a/-196b-5p downregulated the mRNAexpression of IL-1β and TNFα in IPEC-J2 cells. Conclusion Our study provides new insight into the role of miRNAs in the intestinal function of piglets after L. reuteriI5007 treatment.
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