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논문 기본 정보

자료유형
학술저널
저자정보
Li Kexin (Jilin University China) Shen Li (Zhengzhou People’s Hospital China) Zheng Pingping (Jilin University China) Wang Yanjun (The Second Hospital of Jilin University China) Wang Lijuan (The First Hospital of Jilin University China) Meng Xiaoli (The Second Hospital of Jilin University China) Lv Yaogai (Jilin University China) Xue Zhiqiang (Jilin University China) Guo Xin (China–Japan Union Hospital of Jilin University China) Zhang Anning (Jilin University China) Pan Pan (Jilin University China) Bi Chunli (Jilin University China) Chen Yang (Jilin University China) Feng Tianyu (Jilin University China) Li Bo (Jilin University China) Jin Lina (Jilin University China) Yao Yan (Jilin University China)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.44 No.1
발행연도
2022.1
수록면
9 - 17 (9page)
DOI
10.1007/s13258-021-01060-9

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Background Increasing epidemic of ischemic stroke (IS) makes it urgent to understand the pathogenesis and regulatory mechanism, previous studies have described microRNAs (miRNAs) is part of the brain's response to ischemia. Objective The aim of this study was to screen potential biomarkers for the prediction and novel treatment of IS. Methods Differentially expressed miRNAs were screened from three newly diagnosed IS patients and three controls by RNA sequencing technology. Furthermore, target prediction databases were then used to analysis the target genes of different expressed miRNAs, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database were used to identify the functions and the main biochemical and signal pathways of differentially expressed target genes. Results Our results revealed that 27 miRNAs were differentially expressed in IS, among which, hsa-miR-659-5p was the most highly increased and was first found to be associated with IS. In addition, KEGG pathway analyses showed that differentially expressed miRNAs were mainly significantly enriched in lysosome pathway, cytokine-cytokine receptor interaction pathway, spliceosome pathway, base excision repair pathway. Conclusions miRNAs were involved in IS pathogenesis, and hsa-miR-659-5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study.

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