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논문 기본 정보

자료유형
학술저널
저자정보
이미영 (연세대학교) 현대성 (Yonsei University Wonju College of Medicine) 허지혜 (Yonsei University Wonju College of Medicine) 김해경 (Yonsei University Wonju College of Medicine) 한설기 (Yonsei University Wonju College of Medicine) 김장영 (연세대학교) 고상백 (연세대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.34 No.4
발행연도
2019.1
수록면
390 - 397 (8page)

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Background: The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase(GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index usingdata from the large-scale Korean Genome and Epidemiology Study (KoGES). Methods: We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested morethan 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence ofmetabolic syndrome according to GGT quartiles in both genders. Results: The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92±48.20mg/dL vs. 25.62±33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in bothmale and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95%CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predictingrisk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women. Conclusion: We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.

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