Cardiorenal Protection in Diabetic Kidney Disease

Jason F. Lee; Ecaterina Berzan; Vikas S. Sridhar; Ayodele Odutayo; David Z.I. Cherney

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자료유형: 학술저널

저자정보: Jason F. Lee (University of Toronto) Ecaterina Berzan (University of Toronto) Vikas S. Sridhar (University of Toronto) Ayodele Odutayo (University of Toronto) David Z.I. Cherney (University of Toronto)

저널정보: 대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.2

발행연도: 2021.1

수록면: 256 - 269 (14page)

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Over the last 5 years there have been many new developments in the management of diabetic kidney disease. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT2) inhibitors were initially used for glycemic control, but more recent studies have now shown that their benefits extend to cardiovascular and kidney outcomes. The recent additionof data on the novel mineralocorticoid receptor antagonist (MRA) gives us another approach to further decrease the residual risk ofdiabetic kidney disease progression. In this review we describe the mechanism of action, key studies, and possible adverse effects related to these three classes of medications. The management of type 2 diabetes now includes an increasing number of medicationsfor the management of comorbidities in a patient population at significant risk of cardiovascular disease and progression of chronickidney disease. It is from this perspective that we seek to outline the rationale for the sequential and/or combined use of SGLT2 inhibitors, GLP-1 RA and MRAs in patients with type 2 diabetes for heart and kidney protection.

#Diabetes mellitus #type 2 #Diabetic nephropathies #Heart failure #Cardiovascular diseases #Glucagon-like peptide-1 receptor #Mineralocorticoid receptor antagonists #Sodium-glucose transporter 2 inhibitors #Renal insufficiency #chronic

참고문헌 (106)

참고문헌 신청

Tuttle KR / 2020 / Sodium glucose cotransporter 2 inhibition heralds a call-to-action for diabetic kidney disease / Clin J Am Soc Nephrol 15:285~288

Tsapas A / 2020 / Comparative effectiveness of glucose-lowering drugs for type 2 diabetes : a systematic review and network meta-analysis / Ann Intern Med 173:278~286

Sridhar VS / 2020 / What have we learned about renal protection from the cardiovascular outcome trials and observational analyses with SGLT2 inhibitors? / Diabetes Obes Metab 22(Suppl 1):55~68

Lytvyn Y / 2020 / The new biology of diabetic kidney diseasemechanisms and therapeutic implications / Endocr Rev 41:202~231

Dubrofsky L / 2020 / Sodium-glucose cotransporter-2 inhibitors in nephrology practice : a narrative review / Can J Kidney Health Dis 7:2054358120935701

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