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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 179 - 185 (7page)
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Purpose: Carcinoembryonic antigen (CEA) is a useful marker for rectal cancer. The aim of this study was to investigate the prognostic impact of CEA level according to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer patients who underwent radical surgery. Methods: A total of 245 patients with rectal cancer who underwent radical surgery were retrospectively evaluated. Serum CEA level was measured preoperatively and postoperatively. We compared survival outcomes based on CEA level before and after surgery according to nCRT. Results: Of the 245 patients, elevation of CEA level was observed preoperatively in 79 and postoperatively in 30, respec- tively. Eighty-seven (35.5%) patients received nCRT, and elevated CEA level was a significant prognostic factor both be- fore and after surgery. In patients who had not received nCRT, an elevated CEA level was a significant prognostic factor before surgery but was not significant after surgery. In a multivariate analysis for prognostic factors, elevation of preopera- tive CEA level was an independent prognostic factor of disease-free survival (DFS) regardless of nCRT. Postoperative CEA level was an independent prognostic factor of DFS in patients who had received nCRT but was not a factor in pa- tients who had not received nCRT. Conclusion: Serum CEA level was an independent prognostic factor both preoperatively and postoperatively in rectal cancer patients who had received nCRT.
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참고문헌 (33)
참고문헌 신청
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Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Yang Y / 2015 / Prognostic value of perineural invasion in colorectal cancer: a meta-analysis / J Gastrointest Surg 19:1113~1122
Dienstmann R / 2015 / Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients / J Clin Oncol 33:1787~1796
Duffy MJ / 2014 / Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update / Int J Cancer 134:2513~2522
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Yang Y / 2015 / Prognostic value of perineural invasion in colorectal cancer: a meta-analysis / J Gastrointest Surg 19:1113~1122
Dienstmann R / 2015 / Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients / J Clin Oncol 33:1787~1796
Duffy MJ / 2014 / Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update / Int J Cancer 134:2513~2522
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Prognostic value of carcinoembryonic antigen levels before and after curative surgery in colon cancer patients
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Carcinoembryonic Antigen Improves the Performance of Magnetic Resonance Imaging in the Prediction of Pathologic Response after Neoadjuvant Chemoradiation for Patients with Rectal Cancer
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Prognostic Value of CEA Levels before And after Curative Surgery in Colon Cancer Patients
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대장암 환자의 혈장 carcinoembryonic antigen (CEA)와 세포내 CEA 염색패턴의 상관관계와 예후 분석
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Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer
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Neutrophil to Lymphocyte Ratio: A Predictive Marker for Treatment Outcomes in Patients With Rectal Cancer Who Underwent Neoadjuvant Chemoradiation Followed by Surgery
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Prognostic role of preoperative carcinoembryonic antigen levels in colorectal cancer: propensity score matching
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The prognostic significance and treatment modality for elevated pre- and postoperative serum CEA in colorectal cancer patients
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Clinical Significance of Discordance between Carcinoembryonic Antigen Levels and RECIST in Metastatic Colorectal Cancer
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A Prognostic Model To Predict Survival In Stage III Colon Cancer Patients Based on Histological Grade, Preoperative Carcinoembryonic Antigen Level and the Neutrophil Lymphocyte Ratio
Asian Pacific journal of cancer prevention : APJCP
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Long-term oncologic outcomes of neoadjuvant concurrent chemoradiotherapy with capecitabine and radical surgery in locally advanced rectal cancer : 10-year experiences at a single institution
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Treatment outcomes of neoadjuvant concurrent chemoradiotherapy followed by esophagectomy for patients with esophageal cancer
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Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer?
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