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논문 기본 정보

자료유형
학술저널
저자정보
Shiyu Mao (Tongji University School of Medicine) Yuan Wu (Anhui Medical University) Ruiliang Wang (Tongji University School of Medicine) Yadong Guo (Tongji University School of Medicine) Jing Yuan (Tongji University School of Medicine) Wentao Zhang (Tongji University School of Medicine) Junfeng Zhang (Tongji University School of Medicine) Yang Yan (Tongji University School of Medicine) Xudong Yao (Tongji University School of Medicine)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.61 No.4
발행연도
2020.1
수록면
382 - 389 (8page)

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Purpose: Perioperative glucocorticoids have the potential to increase the risk of tumor metastasis. However, the relationship between perioperative glucocorticoids and oncologic outcomes remains controversial. The present study was undertaken to evaluate the association of perioperative glucocorticoids with clinicopathologic outcomes following radical cystectomy (RC). Materials and Methods: We screened and included 185 patients who underwent radical surgery for bladder cancer in our center between 2009 and 2018. The Kaplan–Meier method was applied, and a log-rank test was used to estimate differences in metastasis-free survival (MFS) and overall survival (OS) between the groups. Multivariate Cox proportional hazards regression models were used to analyze any association of glucocorticoids with clinical outcomes. Results: A total of 76 (41.1%) patients received perioperative glucocorticoids. Median postoperative follow-up was 2.0 years. Kaplan–Meier survival curve indicated that the glucocorticoids group was significantly associated with increased distant MFS (p=0.008) but not with OS. In the multivariate analysis, no significant differences were observed for MFS between the groups. Interestingly, when the variable of blood transfusion was excluded from the multivariate analysis model, we found that patients receiving glucocorticoids were independently associated with worse MFS (hazard ratio, 1.790; p=0.030). Furthermore, the partial correlation analysis showed a significant positive correlation between perioperative glucocorticoids and blood transfusion (r=0.604, p<0.001). In the nontransfusion subgroup, propensity score matching showed that patients receiving glucocorticoids had a higher risk of distant metastasis. Conclusions: Perioperative glucocorticoids were associated with a higher rate of distant metastasis in patients undergoing RC for bladder cancer.
#Glucocorticoids #Neoplasm metastasis #Surgery #Urinary bladder neoplasms

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참고문헌 (30)

참고문헌 신청
Anke Richters / 2020 / The global burden of urinary bladder cancer: an update / World Journal of Urology 38(8):1895~1904 Crossref Blaschke S / 2016 / Hematogenous tumor cell spread following standard transurethral resection of bladder carcinoma / Eur Urol 70:544~545 google schola Koch M / 2005 / Detection of hematogenous tumor cell dissemination predicts tumor relapse in patients undergoing surgical resection of colorectal liver metastases / Ann Surg 241:199~205 google schola Snyder GL / 2010 / Effect of anaesthetic technique and other perioperative factors on cancer recurrence / Br J Anaesth 105:106~115 google schola Gündisch S / 2012 / Glucocorticoids augment survival and proliferation of tumor cells / Anticancer Res 32:4251~4261 google schola

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