지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 69 - 80 (12page)
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초록· 키워드
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Background and Objectives: There are no data comparing clinical outcomes of complex percutaneous coronary intervention (PCI) between biodegradable polymer-biolimus-eluting stents (BP-BES) and durable polymer-everolimus-eluting stents (DP-EES). We sought to evaluate the safety and efficacy of BP-BES compared with DP-EES in patients undergoing complex PCI. Methods: Patients enrolled in the SMART-DESK registry were stratified into 2 categories based on the complexity of PCI. Complex PCI was defined as having at least one of the following features: unprotected left main lesion, ≥2 lesions treated, total stent length >40 mm, minimal stent diameter ≤2.5 mm, or bifurcation as target lesion. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (TV-MI), or target lesion revascularization (TLR) at 2 years of follow-up. Results: Of 1,999 patients, 1,145 (57.3%) underwent complex PCI: 521 patients were treated with BP-BES and 624 with DP-EES. In propensity-score matching analysis (481 pairs), the risks of TLF (3.8% vs. 5.2%, adjusted hazard ratio [HR], 0.578; 95% confidence interval [CI], 0.246–1.359; p=0.209), cardiac death (2.5% vs. 2.5%, adjusted HR, 0.787; 95% CI, 0.244–2.539; p=0.689), TV-MI (0.5% vs. 0.4%, adjusted HR, 1.128; 95% CI, 0.157–8.093; p=0.905), and TLR (1.1% vs. 2.9%, adjusted HR, 0.390; 95% CI, 0.139–1.095; p=0.074) did not differ between 2 stent groups after complex PCI. Conclusions: Clinical outcomes of BP-BES were comparable to those of DP-EES at 2 years after complex PCI. Our data suggest that use of BP-BES is acceptable, even for complex PCI.
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참고문헌 (24)
참고문헌 신청
박덕우 / 2005 / Stent Thrombosis in the Era of the Drug-Eluting Stent / Korean Circulation Journal 35(11):791~794
Minha S / 2013 / Second-generation everolimus-eluting stents compared to first-generation drug-eluting stents in patients treated for multivessel disease / J Interv Cardiol 26:561~569
Grundeken MJ / 2016 / First generation versus second generation drug-eluting stents for the treatment of bifurcations : 5-year follow-up of the LEADERS all-comers randomized trial / Catheter Cardiovasc Interv 87:E248~60
Vlachojannis GJ / 2017 / Biodegradable polymer biolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with coronary artery disease : final 5-year report from the COMPARE II trial(abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent) / JACC Cardiovasc Interv 10:1215~1221
Im E / 2016 / Long-term clinical outcomes of a biodegradable polymer-based biolimus-eluting stent / J Interv Cardiol 29:162~167
Minha S / 2013 / Second-generation everolimus-eluting stents compared to first-generation drug-eluting stents in patients treated for multivessel disease / J Interv Cardiol 26:561~569
Grundeken MJ / 2016 / First generation versus second generation drug-eluting stents for the treatment of bifurcations : 5-year follow-up of the LEADERS all-comers randomized trial / Catheter Cardiovasc Interv 87:E248~60
Vlachojannis GJ / 2017 / Biodegradable polymer biolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with coronary artery disease : final 5-year report from the COMPARE II trial(abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent) / JACC Cardiovasc Interv 10:1215~1221
Im E / 2016 / Long-term clinical outcomes of a biodegradable polymer-based biolimus-eluting stent / J Interv Cardiol 29:162~167
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