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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 295 - 304 (10page)
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초록· 키워드
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Background: Proteinuria is a significant risk factor for progression of IgA nephropathy (IgAN) and has a positive correlation with severity of foot process effacement (FPE). We evaluated the relationship of FPE with proteinuria and histologic characteristics, including the Oxford classification. Methods: Patients who underwent renal biopsy and were diagnosed with IgAN at a single center were retrospectively reviewed. Patients aged less than 18 years and those with the possibility of secondary causes were excluded from the study. Subsequently, we evaluated the association between degree of proteinuria, severity of FPE, and histologic characteristics, including the Oxford classification and other immunofluorescence stains. Results: A total of 805 cases of renal biopsy was performed at our institution, and 327 patients were diagnosed with IgAN. Among them, 82 patients were excluded. Severity of FPE had an impact on the degree of proteinuria. Notably, the group with diffuse FPE had more than about 1.3 g/day of urine protein compared to those with rare FPE. Among the histologic characteristics, M1 score and immune deposition of IgG affected severity of FPE (hazard ratios [95% confidence interval], 1.90 [1.10 to 3.26], and 3.77 [1.66 to 8.54], respectively). Conclusion: Severity of FPE had an impact on the degree of proteinuria and may be associated with the pathogenesis of IgAN.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Wyatt RJ / 2013 / IgA nephropathy / N Engl J Med 368:2402~2414
Yasuhiko Tomino / 2016 / Diagnosis and treatment of patients with IgA nephropathy in Japan / Kidney Research and Clinical Practice 35(4):197~203
D’Amico G / 2004 / Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome / Semin Nephrol 24:179~196
Roberts IS / 2014 / Pathology of IgA nephropathy / Nat Rev Nephrol 10:445~454
Robert T / 2015 / Molecular insights into the pathogenesis of IgA nephropathy / Trends Mol Med 21:762~775
Yasuhiko Tomino / 2016 / Diagnosis and treatment of patients with IgA nephropathy in Japan / Kidney Research and Clinical Practice 35(4):197~203
D’Amico G / 2004 / Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome / Semin Nephrol 24:179~196
Roberts IS / 2014 / Pathology of IgA nephropathy / Nat Rev Nephrol 10:445~454
Robert T / 2015 / Molecular insights into the pathogenesis of IgA nephropathy / Trends Mol Med 21:762~775
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