지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 30 - 38 (9page)
이용수
초록· 키워드
오류제보하기
Background: IgA nephropathy (IgAN) is the most common form of glomerulonephritis, a principal cause of end-stage renal disease (ESRD) worldwide. The mechanisms of onset and progression of IgAN have not been fully revealed, and epidemiologic studies have yielded diverging opinions as to the role of occupational exposure to organic solvents in the initiation or worsening of IgAN. As the authors encountered a laboratory worker with IgAN that progressed to ESRD, we present a case report of IgAN progression due to dichloromethane exposure along with a review of literature.
Case presentation: A 41-year-old male laboratory worker began to experience gross painless hematuria after two years of occupational exposure to toluene. Although clinical follow-up was initiated under the impression of IgAN based on clinical findings, the patient continued to work for four more years in the same laboratory, during which he was in charge of laboratory analysis with direct exposure to a high concentration of dichloromethane without proper protective equipment. During that time, his renal function rapidly worsened and finally progressed to ESRD 10 years after the first clinical symptoms. The result of exposure assessment through reenactment of his work exceeded the occupational exposure limit for dichloromethane to a considerable degree.
Conclusions: The causal association between occupational solvent exposure and IgAN is still unclear; therefore, this case report could be used as a basis to support the relevance of occupational solvent exposure to IgAN and/or its progression. Early intervention as well as close monitoring of laboratory workers exposed to various organic solvents is important to prevent or delay the progression of glomerulonephritis to ESRD in the occupational setting.
Case presentation: A 41-year-old male laboratory worker began to experience gross painless hematuria after two years of occupational exposure to toluene. Although clinical follow-up was initiated under the impression of IgAN based on clinical findings, the patient continued to work for four more years in the same laboratory, during which he was in charge of laboratory analysis with direct exposure to a high concentration of dichloromethane without proper protective equipment. During that time, his renal function rapidly worsened and finally progressed to ESRD 10 years after the first clinical symptoms. The result of exposure assessment through reenactment of his work exceeded the occupational exposure limit for dichloromethane to a considerable degree.
Conclusions: The causal association between occupational solvent exposure and IgAN is still unclear; therefore, this case report could be used as a basis to support the relevance of occupational solvent exposure to IgAN and/or its progression. Early intervention as well as close monitoring of laboratory workers exposed to various organic solvents is important to prevent or delay the progression of glomerulonephritis to ESRD in the occupational setting.
목차
Abstract
Background
Case presentation
Discussion
Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical significance of serum galactose-deficient immunoglobulin A1 for detection of recurrent immunoglobulin A nephropathy in kidney transplant recipients
Kidney Research and Clinical Practice
2021 .01
-
Biomarker for recurrent immunoglobulin A nephropathy in kidney allografts: promising but still a long way to go
Kidney Research and Clinical Practice
2021 .01
-
Newly diagnosed pediatric immunoglobulin A nephropathy after vaccination against SARS-CoV-2: a case report
Childhood Kidney Diseases
2022 .12
-
External validation of the international prediction tool in Korean patients with immunoglobulin A nephropathy
Kidney Research and Clinical Practice
2022 .09
-
IgA 신장병의 장기 추적에 따른 임상 경과 및 예후 인자
대한내과학회지
2015 .01
-
Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of IgA nephropathy
Kidney Research and Clinical Practice
2021 .01
-
유기합성실험실 연구자의 단위작업별 노출 평가
한국산업보건학회지
2019 .01
-
Aberrant Blood Vessel Formation Connecting the Glomerular Capillary Tuft and the Interstitium Is a Characteristic Feature of Focal Segmental Glomerulosclerosis-like IgA Nephropathy
Journal of Pathology and Translational Medicine
2016 .01
-
Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
Intestinal research
2021 .10
-
Occupational health of laboratory animal workers
한국실험동물학회 학술발표대회 논문집
2019 .01
-
A Case of Toxic Encephalopathy in a Male with Occupational Dichloromethane Exposure
대한직업환경의학회 학술대회 논문집
2018 .05
-
Severity of foot process effacement is associated with proteinuria in patients with IgA nephropathy
Kidney Research and Clinical Practice
2020 .01
-
A multicenter, randomized, open-label, comparative, phase IV study to evaluate the efficacy and safety of combined treatment with mycophenolate mofetil and corticosteroids in advanced immunoglobulin A nephropathy
Kidney Research and Clinical Practice
2022 .07
-
Association of HLA-DRB1 and -DQB1 Alleles with Susceptibility to IgA Nephropathy in Korean Patients
Annals of Laboratory Medicine
2022 .01
-
Smoking-Related Renal Histologic Injury in IgA Nephropathy Patients
Yonsei Medical Journal
2016 .01
-
Relationship between occupational sunlight exposure and the incidence of renal cancer
대한직업환경의학회지
2019 .12
-
노출평가 방법론에 대한 과거와 현재, 그리고 미래
한국환경보건학회지
2022 .06
-
저농도 유기용제 노출 사업장 근로자의 심혈관질환 위험인자 변화 추적(2008~2012)
한국직업건강간호학회지
2015 .01
-
의료인의 직업적 방사선 노출과 건강 영향
대한내과학회지
2018 .01
-
Beneficial effects of tonsillectomy plus steroid pulse therapy on inflammatory and tubular markers in patients with IgA nephropathy
Kidney Research and Clinical Practice
2016 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
임금근로자의 물리적 작업 위험 요인과 피로의 연관성 분석 : 2011 근로환경조사
김규성
,
백도명
,
김규리
외 2명
대한직업환경의학회 학술대회 논문집
2016
.11
임금근로자의 근무관련요인과 주관적 건강인식의 관계 : 2011 근로환경조사
정재엽
,
백도명
,
김규리
외 2명
대한직업환경의학회 학술대회 논문집
2016
.11
우리나라 임금근로자에서의 감정 노동과 업무상 손상의 관련성 : 2011 근로환경조사
정재엽
,
백도명
,
김규리
외 2명
대한직업환경의학회 학술대회 논문집
2016
.05
화학물질의 건강위험성과 냄새 역치
윤충식
보건학논집
2016
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-517-001156786