Changes in metabolic parameters and adverse kidney and cardiovascular events during glomerulonephritis and renal vasculitis treatment in patients with and without diabetes mellitus

Lim Cynthia Ciwei; Choo Jason CJ; Tan Hui Zhuan; Mok Irene YJ; Chin Yok Mooi; Chan Choong Meng; Woo Keng Thye

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자료유형: 학술저널

저자정보: Lim Cynthia Ciwei (Department of Renal Medicine Singapore General Hospital Singapore) Choo Jason CJ (Department of Renal Medicine Singapore General Hospital Singapore) Tan Hui Zhuan (Department of Renal Medicine Singapore General Hospital Singapore) Mok Irene YJ (Department of Renal Medicine Singapore General Hospital Singapore) Chin Yok Mooi (Department of Renal Medicine Singapore General Hospital Singapore) Chan Choong Meng (Department of Renal Medicine Singapore General Hospital Singapore) Woo Keng Thye (Department of Renal Medicine Singapore General Hospital Singapore)

저널정보: 대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.2

발행연도: 2021.1

수록면: 250 - 262 (13page)

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Background: Cardiovascular disease causes significant morbidity and mortality in patients with glomerulonephritis, which is increasingly diagnosed in older individuals who may have diabetes mellitus (DM). We evaluated the impact of DM on metabolic profile, renal and cardiovascular outcomes during treatment and follow-up of individuals with glomerulonephritis. Methods: We performed a retrospective cohort study of 601 consecutive adults with biopsy-proven glomerulonephritis for factors associated with kidney failure, hospitalization for cardiovascular events, and death. Biopsies with isolated diabetic nephropathy were excluded. Results: The median patient age was 49.8 years (36.7–60.9 years) with estimated glomerular filtration rate of 56.7 mL/min/1.73 m2 (27.7–93.2 mL/min/1.73 m2 ). DM was present in 25.4%. The most frequent diagnoses were minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) (29.5%), lupus nephritis (21.3%), immunoglobulin A (IgA) nephropathy (19.1%), and membranous nephropathy (12.1%). The median follow-up was 38.8 months (interquartile range [IQR], 26.8–55.8 months). Among 511 individuals with lupus nephritis, anti-neutrophil cytoplasmic antibody-associated vasculitis, MCD/FSGS, membranous nephropathy, and IgA nephropathy, 52 (10.2%) developed kidney failure at a median 16.4 months (IQR, 2.3–32.2 months), while 29 (5.7%) had cardiovascular-related hospitalizations at 12.9 months (IQR, 4.8–31.8 months) and 31 (6.1%) died at 13.5 months (IQR, 2.5–42.9 months) after diagnosis. Cox regression analysis found that baseline DM was independently associated with kidney failure (adjusted hazard ratio [HR], 2.07; 95% confidence interval [CI], 1.06–4.05, p = 0.03) and cardiovascular-related hospitalization (adjusted HR, 2.69; 95% CI, 1.21–5.98, p = 0.02) but not with mortality. Conclusion: DM was strongly associated with kidney failure and hospitalization for cardiovascular events in patients with biopsy-proven glomerulonephritis.

#Cardiovascular diseases #Diabetes mellitus #Glomerulonephritis #Renal insufficiency

참고문헌 (53)

참고문헌 신청

Haynes R / 2014 / Evaluating the contribu"tion of the cause of kidney disease to prognosis in CKD : results from the Study of Heart and Renal Protection(SHARP) / Am J Kidney Dis 64:40~48

Wakai K / 2004 / Trends in incidence of endstage renal disease in Japan, 1983-2000 : age-adjusted and age-specific rates by gender and cause / Nephrol Dial Transplant 19:2044~2052

Yang WC / 2008 / Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001 : the impact of national health insurance / Nephrol Dial Transplant 23:3977~3982

GBD 2017 Causes of Death Collaborators / 2018 / Global, regional, and national age-sex-specific mortality for 282 causes of death in 195countries and territories, 1980-2017 : a systematic analysis for the Global Burden of Disease Study 2017 / Lancet 392:1736~1788

Cunningham A / 2018 / Trends in biopsy-based diagnosis of kidney disease : a population study / Can J Kidney Health Dis 5:2054358118799690

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