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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 95 - 101 (7page)
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초록· 키워드
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Background and Objectives: Histamine has been suggested to play an important role during allergic and inflammatory reactions, affecting allergic rhinitis and chronic rhinosinusitis. CXCL8 is a pro-inflammatory chemokine and a critical factor that causes many airway inflammatory diseases including allergic rhinitis and chronic rhinosinusitis.Materials and Method: Histamine cytotoxicity was measured by MTT assay. Real-time polymerase chain reaction was used to identify histamine type 1 receptor in nasal fibroblasts. The fibroblasts were then treated with histamine with or without a histamine type 1 receptor antagonist and the CXCL8 protein was assessed using an enzyme-linked immunosorbent assay (ELISA). The downstream signaling molecules, including phospholipase C and phospho-p50, were evaluated by western blot and immunofluorescent staining.Results: Histamine had no significant cytotoxic effect until the concentration reached 1,000 μM. Histamine type 1 receptor mRNA was expressed in nasal fibroblasts. CXCL8 protein expression level was significantly increased following histamine stimulation. However, the expression level of CXCL8 decreased when phospholipase C was inhibited by U73122. Histamine increased phospho-p50 expression as seen in western blot results. The BAY11-7082, NF-κB inhibitor significantly reduced CXCL8 production in histamine-stimulated nasal fibroblasts.Conclusion: Histamine can induce the production of NF-κB controlled-chemokine CXCL8 by nasal fibroblasts, which supports a role for histamine in upper airway inflammatory diseases.
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참고문헌 (25)
참고문헌 신청
Modena BD / 2016 / Emerging concepts : mast cell involvement in allergic diseases / Transl Res 174:98~121
Stone KD / 2010 / IgE, mast cells, basophils, and eosinophils / J Allergy Clin Immunol 125:S73~80
He SH / 2013 / Mast cells and basophils are essential for allergies : mechanisms of allergic inflammation and a proposed procedure for diagnosis / Acta Pharmacologica Sinica 34:1270~1283
Siracusa MC / 2013 / Basophils and allergic inflammation / J Allergy Clin Immunol 132:789~801
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
Stone KD / 2010 / IgE, mast cells, basophils, and eosinophils / J Allergy Clin Immunol 125:S73~80
He SH / 2013 / Mast cells and basophils are essential for allergies : mechanisms of allergic inflammation and a proposed procedure for diagnosis / Acta Pharmacologica Sinica 34:1270~1283
Siracusa MC / 2013 / Basophils and allergic inflammation / J Allergy Clin Immunol 132:789~801
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
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