Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Ahmed B. Bayoumi; Oyku Ikizgul; Ceren Nur Karaali; Selma Bozkurt; Deniz Konya; Zafer Orkun Toktas

추천

검색

자료유형: 학술저널

저자정보: Ahmed B. Bayoumi (Bahcesehir University School of Medicine) Oyku Ikizgul (Bahcesehir University School of Medicine) Ceren Nur Karaali (Bahcesehir University School of Medicine) Selma Bozkurt (Bahcesehir University School of Medicine) Deniz Konya (Bahcesehir University School of Medicine) Zafer Orkun Toktas (Bahcesehir University School of Medicine)

저널정보: 대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.13 No.6

발행연도: 2019.1

수록면: 1,036 - 1,046 (11page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs as a part of the medical management of diseases of the spine. Our review article describes a systematic method using the PubMed/Medline database with a specific set of keywords to identify such benefits and drawbacks based on 17 original relevant articles published between January 2000 and February 2018; this provides the community of spine surgeons with available cumulative evidence contained within two tables illustrating both observational (10 studies; three cross-sectional, three case-control, and four cohort studies) and interventional (seven randomized clinical trials) studies. While tricyclic antidepressants (e.g., amitriptyline) and duloxetine can be effective in the treatment of neuropathic pain caused by root compression, venlafaxine may be more appropriate for patients with spinal cord injury presenting with depression and/or nociceptive pain. Despite the potential associated consequences of a prolonged hospital stay, higher cost, and controversial reports regarding the lowering of bone mineral density in the elderly, antidepressants may improve patient satisfaction and quality of life following surgery, and reduce postoperative pain and risk of delirium. The preoperative treatment of preexisting psychiatric diseases, such as anxiety and depression, can improve outcomes for patients with spinal cord injury-related disabilities; however, a preoperative platelet function assay is advocated prior to major spine surgical procedures to protect against significant intraoperative blood loss, as serotonergic antidepressants (e.g., selective serotonin reuptake inhibitors) and bupropion can increase the likelihood of bleeding intraoperatively due to drug-induced platelet dysfunction. This comprehensive review of this evolving topic can assist spine surgeons in better understanding the benefits and risks of antidepressant drugs to optimize outcomes and avoid potential hazards in a spine surgical setting.

#Spine surgery #Clinical outcomes #Antidepressive agents #Systematic review

참고문헌 (31)

참고문헌 신청

Mercier A / 2013 / Evidence of prescription of antidepressants for non-psychiatric conditions in primary care : an analysis of guidelines and systematic reviews / BMC Fam Pract 14:55

Bajwa SJ / 2015 / Pain management following spinal surgeries : an appraisal of the available options / J Craniovertebr Junction Spine 6:105~110

Aalto TJ / 2006 / Preoperative predictors for postoperative clinical outcome in lumbar spinal stenosis : systematic review / Spine(Phila Pa 1976) 31:E648~E663

Richards JS / 2015 / Efficacy of venlafaxine XR for the treatment of pain in patients with spinal cord injury and major depression : a randomized, controlled trial / Arch Phys Med Rehabil 96:680~689

Craig A / 2009 / Psychological morbidity and spinal cord injury : a systematic review / Spinal Cord 47:108~114

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!