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A transcription factor Sry-related high mobility group box (Sox) 17 is involved in developmental processes including spermatogenesis, cardiovascular system, endoderm formation, and so on. In this article, we firstly review the studies on the relation between the Sox17 expression and tumor malignancy. Although Sox17 positively promotes various tissue development, most of the cancers associated with Sox17 show decreased expression levels of Sox17, and an inverse correlation between Sox17 expression and malignancy is revealed. We briefly discuss the mechanism of such Sox17 down-regulation by focusing on DNA methylation of CpG sites located in the Sox17 gene promoter. Next, we overview the function of Sox17 in the fetal hematopoiesis, particularly in the dorsal aorta in midgestation mouse embryos. The Sox17 expression in hematopoietic stem cell (HSC)-containing intra-aortic hematopoietic cell cluster (IAHCs) is important for the cluster formation with the hematopoietic ability. The sustained expression of Sox17 in adult bone marrow HSCs and the cells in IAHCs of the dorsal aorta indicate abnormalities that are low lymphocyte chimerism and the aberrant proliferation of common myeloid progenitors in transplantation experiments. We then summarize the perspectives of Sox17 research in cancer control. Key Words Transcription factors, Neoplasms, Methylation, Hematopoiesis, Aotra
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참고문헌 (86)
참고문헌 신청
Wilson M / 2002 / Matching SOX : partner proteins and cofactors of the SOX family of transcriptional regulators / Curr Opin Genet Dev 12:441~446
Bowles J / 2000 / Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators / Dev Biol 227:239~255
Tan DS / 2020 / SOX17in cellular reprogramming and cancer / Semin Cancer Biol 67:65~73
Tam PP / 2003 / Early endoderm development in vertebrates : lineage differentiation and morphogenetic function / Curr Opin Genet Dev 13:393~400
Liu Y / 2007 / Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells / Proc Natl Acad Sci USA 104:3859~3864
Bowles J / 2000 / Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators / Dev Biol 227:239~255
Tan DS / 2020 / SOX17in cellular reprogramming and cancer / Semin Cancer Biol 67:65~73
Tam PP / 2003 / Early endoderm development in vertebrates : lineage differentiation and morphogenetic function / Curr Opin Genet Dev 13:393~400
Liu Y / 2007 / Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells / Proc Natl Acad Sci USA 104:3859~3864
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