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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding enzymes which are multi-domain ER effectors carry out 3-dimensional conformation of nascent polypeptides and check misfolded protein aggregation, easing the exit of functional proteins from the ER. Diverse conditions, for instance redox imbalance, alterations in ionic calcium levels, and inflammatory signaling can perturb the functioning of the ER, leading to a build-up of unfolded or misfolded proteins in the lumen. This results in ER stress, and aiming to reinstate protein homeostasis, a well conserved reaction called the unfolded protein response (UPR) is elicited. Equally, in protracted cellular stress or inadequate compensatory reaction, UPR pathway leads to cell loss. Dysfunctional ER mechanisms are responsible for neuronal degeneration in numerous human diseases, for instance Alzheimer’s, Parkinson’s and Huntington’s diseases. In addition, mounting proof indicates that ER stress is incriminated in psychiatric diseases like major depressive disorder, bipolar disorder, and schizophrenia. Accumulating evidence suggests that pharmacological agents regulating the working of ER may have a role in diminishing advancing neuronal dysfunction in neuropsychiatric disorders. Here, new findings are examined which link the foremost mechanisms connecting ER stress and cell homeostasis. Furthermore, a supposed new pathogenic model of major neuropsychiatry disorders is provided, with ER stress proposed as the pivotal step in disease development.
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참고문헌 (70)
참고문헌 신청
Fu XL / 2014 / Endoplasmic reticulum proteins quality control and the unfolded protein response: the regulative mechanism of organisms against stress injuries / Biofactors 40:569~585
Jovaisaite V / 2014 / The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease / J Exp Biol 217:137~143
van Oosten-Hawle P / 2014 / Transcellular chaperone signaling:an organismal strategy for integrated cell stress responses / J Exp Biol 217:129~136
Inagi R / 2014 / Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease / Nat Rev Nephrol 10:369~378
Freeman OJ / 2016 / The UPR and synaptic dysfunction in neurodegeneration / Brain Res 1648:530~537
Jovaisaite V / 2014 / The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease / J Exp Biol 217:137~143
van Oosten-Hawle P / 2014 / Transcellular chaperone signaling:an organismal strategy for integrated cell stress responses / J Exp Biol 217:129~136
Inagi R / 2014 / Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease / Nat Rev Nephrol 10:369~378
Freeman OJ / 2016 / The UPR and synaptic dysfunction in neurodegeneration / Brain Res 1648:530~537
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