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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 92 - 100 (9page)
- DOI
- https://doi.org/10.3904/kjm.2021.96.2.92
이용수
초록· 키워드
오류제보하기
Nonalcoholic fatty liver disease (NAFLD) is a major public health problem with comorbidities including obesity and dyslipidemia. Although the manifestations of NAFLD range from simple steatosis to non-alcoholic steatohepatitis, these may potentially give rise to liver cirrhosis and hepatocellular carcinoma. However, the mechanisms underlying NAFLD, and the factors that determine the individual risk of disease progression, remain poorly known. The most obvious clinicopathological characteristic of NAFLD is hepatic lipid accumulation and subsequent inflammation. In hepatocytes, the endoplasmic reticulum (ER) is a critical site of protein synthesis, detoxification, lipid and glucose metabolism, and Ca2+ homeostasis; the ER is involved in NAFLD pathogenesis. Hepatic accumulation of lipids stresses the ER; this activates the unfolded protein response (UPR), which is classically viewed as an adaptive pathway that maintains ER homeostasis. Recent studies have revealed that UPR sensors regulate hepatic steatosis and the cellular response to lipotoxic stress. Therefore, the basic mechanisms of ER stress and UPR induction are of great interest for understanding the pathogenesis of NAFLD. The present review focuses on the roles played by ER stress and the UPR in NAFLD pathogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (74)
참고문헌 신청
Ashraf NU / 2015 / Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease / Free Radic Res 49:1405~1418
Seung Ha Park / 2020 / Trends in the prevalence of chronic liver disease in the Korean adult population, 1998–2017 / Clinical and Molecular Hepatology 26(2):209~215
Ascha MS / 2010 / The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis / Hepatology 51:1972~1978
Xu C / 2005 / Endoplasmic reticulum stress : cell life and death decisions / J Clin Invest 115:2656~2664
Schröder M / 2008 / Endoplasmic reticulum stress responses / Cell Mol Life Sci 65:862~894
Seung Ha Park / 2020 / Trends in the prevalence of chronic liver disease in the Korean adult population, 1998–2017 / Clinical and Molecular Hepatology 26(2):209~215
Ascha MS / 2010 / The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis / Hepatology 51:1972~1978
Xu C / 2005 / Endoplasmic reticulum stress : cell life and death decisions / J Clin Invest 115:2656~2664
Schröder M / 2008 / Endoplasmic reticulum stress responses / Cell Mol Life Sci 65:862~894
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