지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria, is a common chronic inflammatory skin disorder that has a prevalence of 0.5% to 1% in the general population. It affects daily normal life and work productivity, with significant impacts on quality of life. Generally, the management of CSU uses a step-wise approach. Although second-generation H1 antihistamines are an effective mainstay of CSU, approximately 20% of patients are resistant to conventional antihistamine monotherapy. Evidence-based and expert consensus-based treatment guidelines of CSU can be a useful resource for primary care physicians and specialists. This review presents diverse information to support decision-making for individualized treatment plans in this special population. Several major therapeutic advances have occurred in recent years. Omalizumab, an immunoglobulin G humanized monoclonal anti-immunoglobulin E antibody that prevents binding of immunoglobulin E to the high-affinity immunoglobulin E receptor has shown safety and efficacy in patients with intractable CSU. In well-controlled clinical trials in patients with refractory CSU who received add-on therapy with subcutaneous omalizumab (300 mg every 4 weeks for 12 or 24 weeks), the rates of complete response were significantly higher in the omalizumab group (relative risk, 4.55; P<0.0001). The introduction of omalizumab as an add-on therapy to H1 antihistamines as a management option has markedly improved the therapeutic possibilities for CSU and the quality of life of CSU patients. Nevertheless, many patients still do not tolerate or benefit from existing therapies, including omalizumab. There are ongoing studies investigating the treatment potential of novel therapeutic targets in CSU.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Zuberbier T / 2018 / The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria / Allergy 73:1393~1414
이나미 / 2017 / Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014 / Allergy, Asthma & Immunology Research 9(5):438~445
Kim YS / 2018 / Prevalence and incidence of chronic spontaneous urticaria in the entire Korean adult population / Br J Dermatol 178:976~977
이승진 / 2017 / Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children / Allergy, Asthma & Immunology Research 9(3):212~219
김윤섭 / 2018 / Clinical Course of Chronic Spontaneous Urticaria in the Korean Adult Population / Allergy, Asthma & Immunology Research 10(1):83~87
이나미 / 2017 / Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014 / Allergy, Asthma & Immunology Research 9(5):438~445
Kim YS / 2018 / Prevalence and incidence of chronic spontaneous urticaria in the entire Korean adult population / Br J Dermatol 178:976~977
이승진 / 2017 / Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children / Allergy, Asthma & Immunology Research 9(3):212~219
김윤섭 / 2018 / Clinical Course of Chronic Spontaneous Urticaria in the Korean Adult Population / Allergy, Asthma & Immunology Research 10(1):83~87
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