지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Pancreatic neuroendocrine tumors (PNETs) are rare tumors with malignant potential, but their incidence has appreciably increased over the last few decades. Diagnosis of PNETs is often difficult with conventional imaging methods. Cross-sectional imaging localizes less than 10% of PNETs less than 1 cm in diameter. Endoscopic ultrasound (EUS) has been shown to be superior to other imaging techniques in the preoperative localization and diagnosis of PNETs. The finding of a hyperenhanced lesion on contrastenhanced EUS was highly predictive of PNETs different from adenocarcinoma. Preoperative assessment of tumor differentiation and Ki-67 is an important prognostic factor for grading. Thus, EUS-guided fine needle biopsy may play a key role in the work-up of nonfunctioning PNETs, and attempts to measure Ki-67 on cytologic and histologic samples have been made. According to the European Neuroendocrine Tumor Society guidelines, there is no clear evidence of a survival benefit of surgery for nonfunctioning G1 PNETs <2 cm in diameter. The benefits of curative surgery must be weighed against operative morbidity and mortality. Although surgical resection remains the mainstay for PNETs, EUS-guided ablation offers a relatively safe and effective treatment option in patients deemed unfit for, or who do not want to undergo, surgery. EUS-guided ablation provides an attractive therapeutic nonsurgical option for patients; however, further studies that better elucidate the long-term outcomes with standardization of technique will help define its role in the treatment of PNETs. The role of EUS in the diagnosis
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참고문헌 (50)
참고문헌 신청
Oberg K / 2005 / Endocrine tumours of the pancreas / Best Pract Res Clin Gastroenterol 19:753~781
Franko J / 2010 / Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients / J Gastrointest Surg 14:541~548
최준호 / 2015 / The Expanding Role of Contrast-Enhanced Endoscopic Ultrasound in Pancreatobiliary Disease / Gut and Liver 9(6):707~713
Yang J / 2014 / Diagnostic role of Gallium-68 DOTATOC and Gallium-68 DOTATATE PET in patients with neuroendocrine tumors : a meta-analysis / Acta Radiol 55:389~398
Kitano M / 2019 / Impact of endoscopic ultrasonography on diagnosis of pancreatic cancer / J Gastroenterol 54:19~32
Franko J / 2010 / Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients / J Gastrointest Surg 14:541~548
최준호 / 2015 / The Expanding Role of Contrast-Enhanced Endoscopic Ultrasound in Pancreatobiliary Disease / Gut and Liver 9(6):707~713
Yang J / 2014 / Diagnostic role of Gallium-68 DOTATOC and Gallium-68 DOTATATE PET in patients with neuroendocrine tumors : a meta-analysis / Acta Radiol 55:389~398
Kitano M / 2019 / Impact of endoscopic ultrasonography on diagnosis of pancreatic cancer / J Gastroenterol 54:19~32
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