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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 125 - 132 (8page)
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초록· 키워드
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Objectives: The FOURIER trial reported that inhibition of PCSK9 with evolocumab on a background of statin therapy lowered low-density lipoprotein (LDL) cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. Here, we report data from a single center focusing on the effect of a PCSK9 inhibitor antibody on hyperlipidemia. Methods: We enrolled 29 hypercholesterolemia patients who had LDL cholesterol levels ≥ 70 mg per deciliter or non- HDL cholesterol ≥ 100 mg per deciliter and were divided into two groups (placebo n = 14, evolocumab n = 15), and participated in a 72 - 96 week, randomized, double-blind, placebo-controlled trial with statin therapy. Patients were randomly assigned to receive evolocumab (140 mg every 2 weeks or 420 mg monthly) or matched placebo via subcutaneous injection. Lipid changes during follow-up were analyzed. Results: The median LDL cholesterol level at baseline was 88 mg per deciliter, and the average LDL cholesterol level was 101.8 ± 20.0 mg per deciliter. At 4 weeks, the median LDL cholesterol level was 39 mg per deciliter, and the average LDL cholesterol level was 34.8 ± 51.8 mg per deciliter. Compared to placebo group, the LDL cholesterol levels were significantly reduced after treatment (P < 0.001), as well as total cholesterol, ApoB, and ApoB / ApoA1 levels. During follow- up, no discomfort was reported at local injection sites, and no cases of abnormal liver function were observed. Conclusions: Evolocumab significantly reduced LDL cholesterol levels and was well tolerated.
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참고문헌 (16)
참고문헌 신청
Seidah NG / 2003 / The secretory proprotein convertase neural apoptosis-regulated convertase 1(NARC-1) : liver regeneration and neuronal differentiation / Proc Natl Acad Sci U S A 100:928~933
Abifadel M / 2012 / Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia / Atherosclerosis 223:394~400
Elagoz A / 2002 / Biosynthesis and Cellular Trafficking of the Convertase SKI1/S1P Ectodomain Shedding Requires SKI1 Activity / J Biol Chem 277:11265~11275
Giugliano RP / 2015 / Are PCSK9 inhibitors the next breakthrough in the cardiovascular field / J Am Coll Cardiol 65:2638~2651
Rousselet E / 2011 / PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke / J Lipid Res 52:1383~1391
Abifadel M / 2012 / Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia / Atherosclerosis 223:394~400
Elagoz A / 2002 / Biosynthesis and Cellular Trafficking of the Convertase SKI1/S1P Ectodomain Shedding Requires SKI1 Activity / J Biol Chem 277:11265~11275
Giugliano RP / 2015 / Are PCSK9 inhibitors the next breakthrough in the cardiovascular field / J Am Coll Cardiol 65:2638~2651
Rousselet E / 2011 / PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke / J Lipid Res 52:1383~1391
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