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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 228 - 237 (10page)
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초록· 키워드
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Objective: There has been no prospective study that examined intramuscular injection of high-dose vitamin D in Korean adults. The aim of this study was to assess the efficacy and safety of high-dose vitamin D3 after intramuscular injection in Korean adults with vitamin D deficiency. Method: This study was a 24-week, prospective, multicenter, randomized, double-blind, placebo-controlled trial. A total of 84 subjects 19 and <65 years of age were randomly allocated to either the vitamin D3 or placebo group in a 2:1 ratio. After randomization, a single injection of plain vitamin D3 200,000 IU or placebo was intramuscularly administered. If serum 25-hydroxyvitamin D (25[OH]D) concentrations were <30 ng/mL on week 12 or thereafter, a repeat injection was administered. Results: After a single intramuscular injection of vitamin D3 to adults with vitamin D deficiency, the proportion of subjects with serum 25(OH)D concentrations 30 ng/mL within 12 weeks was 46.4% in the vitamin D3 group and 3.6% in the placebo group (p < 0.0001). The proportion of subjects with serum 25(OH)D concentrations 30 ng/mL within 24 weeks was 73.2% in the vitamin D3 group and 3.6% in the placebo group (p < 0.0001). Mean change in serum 25(OH)D concentrations at weeks 12 and 24 after vitamin D3 injection was 12.8 ± 8.1 and 21.5 ± 8.1 ng/ mL, respectively, in the vitamin D3 group, with no significant changes in the placebo group. Serum parathyroid hormone concentrations showed a significant decrease in the vitamin D3 group but no change in the placebo group. Conclusion: Intramuscular injection of vitamin D3 200,000 IU was superior to placebo in terms of its impact on serum 25(OH)D concentrations, and is considered to be safe and effective in Korean adults with vitamin D deficiency.
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참고문헌 (22)
참고문헌 신청
Holick MF / 2007 / Vitamin D deficiency / N Engl J Med 357:266~281
Michael F. Holick / 2012 / Vitamin D: A D-Lightful Vitamin for Health / Endocrinology and Metabolism 27(4):255~267
Giovannucci E / 2006 / Prospective study of predictors of vitamin D status and cancer incidence and mortality in men / J Natl Cancer Inst 98:451~459
Lin J / 2007 / Intakes of calcium and vitamin D and breast cancer risk in women / Arch Intern Med 167:1050~1059
Ginde AA / 2009 / Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey / Arch Intern Med 169:384~390
Michael F. Holick / 2012 / Vitamin D: A D-Lightful Vitamin for Health / Endocrinology and Metabolism 27(4):255~267
Giovannucci E / 2006 / Prospective study of predictors of vitamin D status and cancer incidence and mortality in men / J Natl Cancer Inst 98:451~459
Lin J / 2007 / Intakes of calcium and vitamin D and breast cancer risk in women / Arch Intern Med 167:1050~1059
Ginde AA / 2009 / Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey / Arch Intern Med 169:384~390
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