지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 108 - 113 (6page)
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The main treatment for Antiphospholipid syndrome (APS) is long-term anticoagulation with an oral vitamin K antagonist, although these are associated with numerous problems. Rivaroxaban is a direct anti-factor Xa inhibitor, with a predictable anticoagulant effect at fixed doses. There are limited reports of rivaroxaban use in APS. We present four cases of patients with APS who received rivaroxaban treatment for six months without thrombosis recurrence or bleeding. Three of the patients received rivaroxaban as initial therapy. In the systematic review, only five patients were treated with rivaroxaban as a thromboprophylaxis. Of the 71 cases of rivaroxaban use including our study, there were seven cases (9.9%) of thrombosis recurrence and two reports of bleeding. The efficacy of rivaroxaban in APS patients was at least equal to warfarin therapy. This report and systematic review suggest that rivaroxaban can be considered cautiously as a thromboprophylactic or alternative therapy for warfarin in patients with APS. (J Rheum Dis 2017;24:108-113)
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Miyakis S / 2006 / International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome(APS) / J Thromb Haemost 4:295~306
Ruiz-Irastorza G / 2011 / Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients : report of a task force at the 13th International Congress on antiphospholipid antibodies / Lupus 20:206~218
Erkan D / 2014 / 14th International Congress on Antiphospholipid Antibodies : task force report on antiphospholipid syndrome treatment trends / Autoimmun Rev 13:685~696
EINSTEIN Investigators / 2010 / Oral rivaroxaban for symptomatic venous thromboembolism / N Engl J Med 363:2499~2510
EINSTEIN–PE Investigators / 2012 / Oral rivaroxaban for the treatment of symptomatic pulmonary embolism / N Engl J Med 366:1287~1297
Ruiz-Irastorza G / 2011 / Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients : report of a task force at the 13th International Congress on antiphospholipid antibodies / Lupus 20:206~218
Erkan D / 2014 / 14th International Congress on Antiphospholipid Antibodies : task force report on antiphospholipid syndrome treatment trends / Autoimmun Rev 13:685~696
EINSTEIN Investigators / 2010 / Oral rivaroxaban for symptomatic venous thromboembolism / N Engl J Med 363:2499~2510
EINSTEIN–PE Investigators / 2012 / Oral rivaroxaban for the treatment of symptomatic pulmonary embolism / N Engl J Med 366:1287~1297
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