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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 933 - 941 (9page)
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초록· 키워드
오류제보하기
The combined use of a drug-eluting balloon (DEB) and a bare metal stent (BMS) for the treatment of de novo non-small vessel coronary artery diseases (CAD) remains to be evaluated. We investigated the efficacy of a sequential treatment using a DEB together with a BMS implantation in comparison to a zotarolimus-eluting stent (ZES). This study was a prospective, randomized, open-label study. We designed it to demonstrate the non-inferiority of a sequential treatment using a DEB first followed by a BMS (DEB + BMS) compared with the use of a ZES. The primary endpoint was in-segment late loss (LL) at 9 months measured by quantitative coronary angiography (QCA). A total of 180 patients were enrolled in the study. The 9-month follow-up angiography was performed in 72 patients with DEB + BMS and 74 patients with ZES. When comparing the DEB + BMS results with the ZES ones, LL was 0.50 ± 0.46 mm in DEB + BMS patients vs. 0.21 ± 0.44 mm in ZES patients (P < 0.001). The mean difference of the LL was 0.31 mm, which was larger than the prespecified non-inferiority margin of 0.19 mm, and the 2-sided 95% confidence interval was 0.15–0.48. The clinical outcomes were not significantly different. In conclusion, the DEB + BMS strategy is inferior to the ZES one in terms of the LL result at 9 months. The DEB strategy for de novo coronary artery lesions needs to be improved for it to become an alternative treatment option. This was a clinical trial study and was registered at www.ClinicalTrials.gov (Identifier: NCT01539603; http://www.clinicaltrials.gov/ct2/show/NCT01539603).
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Elezi S / 1998 / Vessel size and long-term outcome after coronary stent placement / Circulation 98:1875~1880
Hoffmann R / 1996 / Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study / Circulation 94:1247~1254
Stettler C / 2007 / Outcomes associated with drug-eluting and bare-metal stents : a collaborative network meta-analysis / Lancet 370:937~948
Nakazawa G / 2008 / Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients : an autopsy study / Circulation 118:1138~1145
Joner M / 2006 / Pathology of drug-eluting stents in humans : delayed healing and late thrombotic risk / J Am Coll Cardiol 48:193~202
Hoffmann R / 1996 / Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study / Circulation 94:1247~1254
Stettler C / 2007 / Outcomes associated with drug-eluting and bare-metal stents : a collaborative network meta-analysis / Lancet 370:937~948
Nakazawa G / 2008 / Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients : an autopsy study / Circulation 118:1138~1145
Joner M / 2006 / Pathology of drug-eluting stents in humans : delayed healing and late thrombotic risk / J Am Coll Cardiol 48:193~202
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