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Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine
Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.32 No.9 KCI Accredited Journals
- 발행연도
- 2017.1
- 수록면
- 1,431 - 1,439 (9page)
이용수
Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine
초록· 키워드
오류제보하기
This study investigated the serotype distribution and antimicrobial resistance of 3,820 nasopharyngeal Streptococcus pneumoniae isolates from infants and children who presented with respiratory symptoms at Seoul National University Children's Hospital from July 2010 to June 2015 after the introduction of the extended-valency pneumococcal conjugate vaccines (PCVs). Serotypes and antimicrobial susceptibility were determined using the Quellung reaction and E-test, respectively. S. pneumoniae was isolated from 397 (10.4%) specimens. The most common serotypes were 19A (14.0%), 23A (12.8%), 15B/C (10.7%), 11A (10.1%), 6C (7.8%), and 6A (6.3%) among the typeable pneumococci (n = 335). The PCV serotype proportions significantly decreased (59.1% in 2010/11 to 17.0% in 2014/15, P < 0.001), whereas the non-PCV serotype proportions significantly increased (40.9% in 2010/11 to 83.0% in 2014/15, P < 0.001). The non-susceptibility rates for penicillin (oral), penicillin (parenteral, non-meningitis), cefotaxime, and erythromycin were 97.8%, 22.8%, 27.7%, and 95.5%, respectively. The proportions of PCV serotypes responsible for non-susceptibility to penicillin (parenteral, non-meningitis) and multidrug resistance significantly decreased (80.8% to 21.1%, P < 0.001 and 64.3% to 12.3%, P < 0.001, respectively), whereas the non-PCV serotype proportions significantly increased (19.2% to 78.9%, P < 0.001 and 35.7% to 87.7%, P < 0.001, respectively). Serotypes 23A and 15B/C demonstrated significant proportional increase among the antibiotics resistant strains. Thus, the PCV serotype proportions decreased and the non-PCV serotype proportions increased among nasopharyngeal carriage pneumococci after the introduction of extended-valency PCVs in Korea. Antimicrobial non-susceptibility rates for penicillin and erythromycin remain high despite the decrease in the proportion of PCV serotypes responsible for antimicrobial resistance over time.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Nuorti JP / 2010 / Prevention of pneumococcal disease among infants and children - use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine - recommendations of the Advisory Committee on Immunization Practices (ACIP) / MMWR Recomm Rep 59:1~18
Bogaert D / 2004 / Streptococcus pneumoniae colonisation : the key to pneumococcal disease / Lancet Infect Dis 4:144~154
Centers for Disease Control and Prevention (CDC) / 2008 / Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction--eight states, 1998–2005 / MMWR Morb Mortal Wkly Rep 57:144~148
Miller E / 2011 / Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales : an observational cohort study / Lancet Infect Dis 11:760~768
Hampton LM / 2012 / Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines / J Infect Dis 205:401~411
Bogaert D / 2004 / Streptococcus pneumoniae colonisation : the key to pneumococcal disease / Lancet Infect Dis 4:144~154
Centers for Disease Control and Prevention (CDC) / 2008 / Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction--eight states, 1998–2005 / MMWR Morb Mortal Wkly Rep 57:144~148
Miller E / 2011 / Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales : an observational cohort study / Lancet Infect Dis 11:760~768
Hampton LM / 2012 / Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines / J Infect Dis 205:401~411
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