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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 950 - 956 (7page)
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초록· 키워드
오류제보하기
Although it is well known that pneumococcal conjugate vaccines provide cross-protection against some vaccine-related serotypes, these mechanisms are still unclear. This study was performed to investigate the role of cross-protective IgM antibodies against vaccinerelated serotypes 6A, 6C, and 19A induced in children aged 12-23 months after immunization with 7-valent pneumococcal conjugate vaccine (PCV7). We obtained serum samples from 18 Korean children aged 12-23 months after a PCV7 booster immunization. The serum IgG and IgM concentrations of serotypes 6B and 19F were measured by enzymelinked immunosorbent assay (ELISA) in serum. The opsonic indices (OIs) against vaccine serotypes 6B and 19F and vaccine-related serotypes 6A, 6C, and 19A were determined by an opsonophagocytic killing assay (OPA) in IgM-depleted and control serum. Both IgG and IgM antibodies in ELISA and opsonic indices in OPA against serotypes 6B and 19F were demonstrated in the immune serum. IgM depletion decreased the OIs against vaccine serotypes 6B (geometric means of OIs (GMIs) of 3,009 vs. 1,396, 38% reduction) and 19F (1,117 vs. 750, 36% reduction). In addition, IgM depletion markedly decreased the OIs against vaccine-related serotypes 6A (GMIs of 961 vs. 329, 70% reduction), 6C (432 vs. 185, 72% reduction), and 19A (301 vs. 166, 58% reduction). The booster immunization PCV7 induced protective antibodies in the form of both IgG and IgM isotypes. IgM antibodies contributed to eliciting cross-protection against vaccine-related serotypes as well as against vaccine serotypes.
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참고문헌 (28)
참고문헌 신청
이준호 / 2011 / Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (1996-2005): A Retrospective Multicenter Study / Journal of Korean Medical Science 26(2):174~183
World Health Organization / 2007 / Pneumococcal conjugate vaccine for childhood immunization--WHO position paper / Wkly Epidemiol Rec 82:93~104
Centers for Disease Control and Prevention / 2008 / Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction--eight states, 1998-2005 / MMWR Morb Mortal Wkly Rep 57:144~148
Hsu KK / 2010 / Changing serotypes causing childhood invasive pneumococcal disease: Massachusetts, 2001-2007 / Pediatr Infect Dis J 29:289~293
Väkeväinen M / 2001 / Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants / J Infect Dis 184:789~793
World Health Organization / 2007 / Pneumococcal conjugate vaccine for childhood immunization--WHO position paper / Wkly Epidemiol Rec 82:93~104
Centers for Disease Control and Prevention / 2008 / Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction--eight states, 1998-2005 / MMWR Morb Mortal Wkly Rep 57:144~148
Hsu KK / 2010 / Changing serotypes causing childhood invasive pneumococcal disease: Massachusetts, 2001-2007 / Pediatr Infect Dis J 29:289~293
Väkeväinen M / 2001 / Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants / J Infect Dis 184:789~793
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