지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,626 - 1,632 (7page)
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초록· 키워드
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Subclinical hyperthyroidism and subclinical hypothyroidism are characterized by abnormal thyroid stimulating hormone (TSH) with normal free thyroxine. Subclinical thyroid diseases, to date, have received less attention compared with other thyroid diseases since they are asymptomatic. This study aimed to verify the association between subclinical thyroid diseases and cardiovascular diseases (CVDs) risk score in the Korean population. This was a population-based cohort study using data collected from 3,722 subjects (aged ≥ 30 years) during the 6th Korea National Health and Nutrition Examination Survey (KNHANES VI; 2013–2015). Gender-specific Framingham risk scores were calculated to identify the association between subclinical thyroid diseases and 10-year CVD risk score. Complex survey, with consideration of sampling weight, was analyzed using generalized linear models after stratification by gender. The TSH reference range was between 0.61 and 6.91 mIU/L in this study. TSH showed a positive association with the 10-year CVD risk score only in the female population (P = 0.001). There were significant differences in the least squares means of 10-year CVD risk score by the effect of subclinical hypothyroidism compared with euthyroidism (normal group) in females, after adjusting for body mass index, white blood cell, and urine iodine (P = 0.006 and Bonferroni corrected P = 0.012). In conclusion, subclinical hypothyroidism is associated with increased 10-year CVD risk score in the female Korean population aged 30 years or more. Therefore, we recommend to clinically checkup major CVD risk factors in female patients with subclinical hypothyroidism aged 30 years or more.
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참고문헌 (36)
참고문헌 신청
Canaris GJ / 2000 / The Colorado thyroid disease prevalence study / Arch Intern Med 160:526~534
Biondi B / 2015 / The 2015 European Thyroid Association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism / Eur Thyroid J 4:149~163
Hak AE / 2000 / Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women : the Rotterdam Study / Ann Intern Med 132:270~278
Ochs N / 2008 / Meta-analysis : subclinical thyroid dysfunction and the risk for coronary heart disease and mortality / Ann Intern Med 148:832~845
Hueston WJ / 2004 / Subclinical hypothyroidism and the risk of hypercholesterolemia / Ann Fam Med 2:351~355
Biondi B / 2015 / The 2015 European Thyroid Association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism / Eur Thyroid J 4:149~163
Hak AE / 2000 / Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women : the Rotterdam Study / Ann Intern Med 132:270~278
Ochs N / 2008 / Meta-analysis : subclinical thyroid dysfunction and the risk for coronary heart disease and mortality / Ann Intern Med 148:832~845
Hueston WJ / 2004 / Subclinical hypothyroidism and the risk of hypercholesterolemia / Ann Fam Med 2:351~355
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