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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,662 - 1,668 (7page)
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The aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis. Logistic regression models were used to determine predictors of recurrence. Median follow-up was 33 months (interquartile range [IQR], 7–50). The numbers of patients with organ-confined and lymph node (LN)-positive disease were 237 (68.4%) and 68 (19.7%), respectively. LN density (1–20 vs. > 20) was 13.6% and 6.1%, with a median of 17 nodes removed (IQR, 9–23). In logistic regression analysis, type of LN dissection, and pathologic tumor stage were significant predictors of cancer recurrence and death from cancer. Local, distal recurrence and secondary UC occurred in 7 (2.0%), 53 (15.3%), and 4 (1.2%) patients, respectively. The 5-year overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were 78%, 84%, and 73%, respectively. At last follow-up, RFS for extended pelvic LN dissection vs. standard pelvic LN dissection was 70% and 47% (P = 0.038). In addition, at last follow-up, LN density (0 vs. 1–20 vs. over 20) was 67%, 41%, and 29%, respectively (P < 0.001). Patients undergoing RARC in this multi-institutional cohort demonstrated intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns that were not unusual.
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참고문헌 (30)
참고문헌 신청
Herr HW / 2009 / Neoadjuvant chemotherapy : a new treatment paradigm for muscle-invasive bladder cancer / Eur Urol 55:303~305
Shariat SF / 2006 / Outcomes of radical cystectomy for transitional cell carcinoma of the bladder : a contemporary series from the Bladder Cancer Research Consortium / J Urol 176:2414~2422
Nix J / 2010 / Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer : perioperative and pathologic results / Eur Urol 57:196~201
Challacombe BJ / 2011 / The role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications / Eur Urol 60:767~775
Styn NR / 2012 / Matched comparison of robotic-assisted and open radical cystectomy / Urology 79:1303~1308
Shariat SF / 2006 / Outcomes of radical cystectomy for transitional cell carcinoma of the bladder : a contemporary series from the Bladder Cancer Research Consortium / J Urol 176:2414~2422
Nix J / 2010 / Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer : perioperative and pathologic results / Eur Urol 57:196~201
Challacombe BJ / 2011 / The role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications / Eur Urol 60:767~775
Styn NR / 2012 / Matched comparison of robotic-assisted and open radical cystectomy / Urology 79:1303~1308
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